Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice.
Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice.
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DOI：
10.1039/c6fo01467d
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发表时间：
2017-03
期刊：
影响因子：
6.1
通讯作者：
Siddhartha M. Sarma;P. Khare;Sneha Jagtap;D. P. Singh;R. Baboota;Koteswaraiah Podili;R. Boparai;Jaspreet Kaur;K. Bhutani;M. Bishnoi;K. Kondepudi
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文献类型：
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作者：
Siddhartha M. Sarma;P. Khare;Sneha Jagtap;D. P. Singh;R. Baboota;Koteswaraiah Podili;R. Boparai;Jaspreet Kaur;K. Bhutani;M. Bishnoi;K. Kondepudi
谷子全谷和麸皮对饮食性肥胖的保护作用尚未研究。在这里，我们研究了谷子补充剂对年龄匹配的瑞士白化病小鼠的作用，这些小鼠随机分为两组，分别喂养16周。高脂肪饮食增加体重，降低葡萄糖耐量，升高血脂，改变肝脏和脂肪细胞基因表达，并引起肠道有益菌的生态失调。添加谷子不影响体重增加，但提高了糖耐量，阻止了血清胆固醇和脂质参数的升高（P≤0.05），调节了脂肪生成相关基因的表达，降低了血清IL-6和LPS水平（P≤0.05），促进了选定的有益肠道细菌丰度(乳杆菌、双双杆菌、提高了盲肠内容物总短链脂肪酸产量（P≤0.05）和乙酸水平（P≤0.05）。本研究提供的证据表明，谷子补充剂可以减轻高脂肪饮食引起的变化，因此可以作为一种功能成分纳入肥胖的管理。
The protective role of kodo millet whole grain and bran supplementation in diet induced obesity has not been investigated. Here we have studied the role of kodo millet supplementation in age matched Swiss albino mice that were randomly divided into groups and fed their respective diets for 16 weeks. A high fat diet increased weight gain, reduced glucose tolerance, increased serum lipids, altered hepatic and adipocyte gene expression and caused dysbiosis in the intestinal beneficial bacteria. Kodo millet supplementation did not affect weight gain but it improved glucose tolerance and prevented an increase in the serum cholesterol and lipid parameters (P ≤ 0.05), modulated adipogenesis related gene expression, decreased serum IL-6 and LPS levels (P ≤ 0.05), promoted selected beneficial gut bacterial abundances (Lactobacillus sp., Bifidobacteria, Akkermansia and Roseburia spp.) and improved the total short chain fatty acid production (P ≤ 0.05) and acetate levels (P ≤ 0.05) in cecal contents. This study provides evidence that kodo millet supplementation alleviates high-fat diet induced changes and hence can be incorporated as a functional ingredient for the management of obesity.