Hepatic circulation in cirrhosis.
Hepatic circulation in cirrhosis.
复制标题
肝硬化时的肝循环。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
D. Marleau
中科院分区：
文献类型：
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作者：
P. Huet;J. Villeneuve;G. Pomier‐Layrargues;D. Marleau
使用多指示剂稀释法，微血管床中发生的事件可以被表征，并且与动脉硬化肝脏中的两种解剖学改变相容：毛细血管化和肝内分流。这两种改变的结合导致血肝交换的进行性限制。肝硬化中肝脏清除内源性和外源性底物的能力降低通常被认为是由肝细胞质量和/或功能降低引起的。我们的数据表明，这些底物的肝摄取异常也可能导致肝硬化肝功能受损。肝窦毛细血管化在整个消除过程中特别重要，而肝内分流（如果存在）进一步加剧毛细血管化的功能效应。
Using the multiple indicator dilution approach, events occurring in the microvascular bed can be characterized and are compatible with the two kinds of anatomical alterations in cirrhotic livers: capillarization and intrahepatic shunts. The combination of these two kinds of alteration contributes to the progressive limitation of the blood-liver exchange. The decreased ability of the liver to clear endogenous and exogenous substrates in cirrhosis is generally thought to result from a reduction of liver cell mass and/or function. Our data suggest that abnormalities in the hepatic uptake of these substrates may also contribute to the impaired liver function in cirrhosis. Capillarization of the hepatic sinusoid is of particular importance in the overall process of elimination while intrahepatic shunts, when present, further exacerbate the functional effects of capillarization.