Suppression of exposure to malaria vectors by an order of magnitude using microbial larvicides in rural Kenya.
Suppression of exposure to malaria vectors by an order of magnitude using microbial larvicides in rural Kenya.
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DOI：
10.1111/j.1365-3156.2006.01733.x
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发表时间：
2006-11-01
期刊：
影响因子：
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通讯作者：
Lindsay, Steven W
中科院分区：
文献类型：
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作者：
Fillinger, Ulrike;Lindsay, Steven W
目的：为了确定的贡献杀幼虫剂可以减少疟疾的负担，进行了试验的微生物杀幼虫剂在4.5平方公里的面积和周围的一个大村庄在农村Kenya.METHOD：未成熟和成年蚊子的丰度进行了监测12个月的基线条件下。然后进行28个月的微生物幼虫控制。干预后，丰富的未成年和成年蚊子进行了监测，为进一步12 months.RESULTS：419蚊子幼虫栖息地确定，336（80%）来自人类活动。苏云金芽孢杆菌的应用。以色列按蚊和球形芽孢杆菌杀幼虫剂将含有按蚊幼虫的水生生境的比例从非干预期间的51%降低到干预期间的7%。晚龄按蚊在栖息地的发生率从干预前和干预后的39%和33%下降到干预期间的0.6%。总体而言，杀幼虫剂使按蚊幼虫密度降低了95%，使人类暴露于成虫叮咬减少了92%。在研究领域的人口提供这种保护的估计成本低于0.90美元/人/year.CONCLUSION：适当应用的微生物杀幼虫剂可以大大降低人类接触疟疾在撒哈拉以南非洲农村地区。
OBJECTIVE: To determine the contribution larviciding could make to reduce the burden of malaria, by conducting a trial of microbial larvicides in a 4.5 km2 area in and around a large village in rural western Kenya.METHOD: The abundance of immature and adult mosquitoes was monitored for 12 months under baseline conditions. Then microbial larval control was implemented for 28 months. After the intervention, the abundance of immature and adult mosquitoes was monitored for a further 12 months.RESULTS: Of the 419 mosquito larval habitats identified, 336 (80%) originated from human activities. Application of Bacillus thuringiensis var. israelensis and Bacillus sphaericus larvicides reduced the proportion of aquatic habitats containing Anopheles larvae from 51% during non-intervention periods to 7% during the intervention. The occurrence of late instar Anopheles in habitats was reduced from 39% and 33% in pre-intervention and post-intervention periods to 0.6% during intervention. Overall, larviciding reduced Anopheles larval density by 95% and human exposure to bites from adults by 92%. The estimated cost of providing this protection to the human population in the study area was less than US$ 0.90/person/year.CONCLUSION: Appropriately applied microbial larvicides can substantially and cost-effectively reduce human exposure to malaria in rural sub-Saharan Africa.