PROGNOSTIC SIGNIFICANCE OF NUCLEAR pSTAT3 IN ORAL CANCER
PROGNOSTIC SIGNIFICANCE OF NUCLEAR pSTAT3 IN ORAL CANCER
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DOI：
10.1002/hed.21468
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发表时间：
2011-04-01
影响因子：
2.9
通讯作者：
Ralhan, Ranju
中科院分区：
文献类型：
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作者：
Macha, Muzafar A.;Matta, Ajay;Ralhan, Ranju
背景资料。蛋白质的异常核积聚影响肿瘤的发展，并可能预测生物侵袭性和疾病预后。本研究探讨pSTAT3(磷酸化信号转导和转录激活因子3)在口腔鳞状细胞癌(OSCCs)中的表达及其预后意义。免疫组织化学结果显示，90例白斑中49例(54.4%)和94例口腔鳞癌中63例(67%)pSTAT3表达明显增加(P<0.01)。PSTAT3的升高与肿瘤分期(p=.01)、淋巴结转移(p=.0018)和烟草消费(p=.004)有关。Kaplan-Meier分析显示，pSTAT3核表达增加的口腔鳞癌患者的无病生存期(13个月)显著低于无核pSTAT3表达的患者(，p=.019)。COX回归分析显示，pSTAT3核是预后不良的最显著预测因素(p=.024，风险比[HR]=2.7)。PSTAT3的核积聚增加发生在癌前病变的早期，是口腔鳞癌预后不良的标志。(C)2010 Wiley期刊公司Head Neck 33：482-489,2011
Background. Aberrant nuclear accumulation of proteins influences tumor development and may predict biologic aggressiveness and disease prognosis. This study determined the prognostic significance of pSTAT3 (phosphorylayed signal transducer and activator of transcription 3) in oral squamous cell carcinomas (OSCCs).Methods and Results. Using immunohistochemistry, a significant increase in nuclear accumulation of pSTAT3 was observed in 49 of 90 leukoplakias (54.4%) and 63/94 OSCCs (67%) (p(trend) < .001). Increased pSTAT3 was associated with tumor stage (p = .01), nodal metastasis (p = .0018), and tobacco consumption (p = .004). Kaplan-Meier analysis demonstrated that OSCC with increased nuclear pSTAT3 showed significantly reduced disease-free survival (13 months), compared with the patients with no nuclear pSTAT3 expression (64 months, p = .019). Cox regression analysis revealed nuclear pSTAT3 as the most significant predictor of poor prognosis (p = .024, hazard ratio [HR] = 2.7).Conclusions. Increased nuclear accumulation of pSTAT3 occurs in early premalignant stages and is a marker for poor prognosis of OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 482-489, 2011