Associations of Hearing Sensitivity, Higher-Order Auditory Processing, and Cognition Over Time in Middle-Aged Adults
Associations of Hearing Sensitivity, Higher-Order Auditory Processing, and Cognition Over Time in Middle-Aged Adults
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DOI：
10.1093/gerona/glz189
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发表时间：
2020-03-01
影响因子：
5.1
通讯作者：
Cruickshanks, Karen J.
中科院分区：
文献类型：
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作者：
Merten, Natascha;Fischer, Mary E.;Cruickshanks, Karen J.
背景 与年龄相关的听力损失（听力敏感性和/或高阶听觉处理受损）和认知能力下降是老年人常见的并发损伤。它们在衰老过程中的关系仍不清楚。我们的目的是评估中年成年人听力敏感性、高阶听觉处理和认知能力下降的时间关系。 方法 这项研究包括 1,274 名 Beaver Dam 后代研究参与者，他们参加了三项检查（基线、5 年和 10 年随访）。我们通过纯音测听（PTA，较好耳朵的平均阈值 0.5、1、2、4 kHz）评估听力灵敏度，使用较好耳朵使用西北大学 6 个单词列表进行竞争信息中的单词识别 (WRCM) 等高阶听觉处理，并通过跟踪测试表现 (TMT) 评估认知。线性混合效应模型和线性回归模型用于确定随时间变化的关联性以及这些测量值随时间变化的相互影响程度。结果 所有功能之间的纵向下降与 PTA 和 WRCM 之间的最强关系相关。 10 年后基线 PTA 对 WRCM 的影响（标准化 ss = -.30）几乎是 10 年后基线 WRCM 对 PTA 的影响（标准化 ss = -.18）的两倍。 10 年后基线 WRCM 对 TMT 的影响很小（标准化 ss = -.05），反之亦然。 PTA 和 TMT 之间没有确定方向关系（标准化 ss
Background Age-related hearing loss (impairment in hearing sensitivity and/or higher-order auditory processing) and cognitive decline are common co-occurring impairments in elderly adults. Their relation in the process of aging remains insufficiently understood. We aim to assess the temporal relations of decline in hearing sensitivity, higher-order auditory processing, and cognition in middle-aged adults.Methods This study included 1,274 Beaver Dam Offspring Study participants who participated in three examinations (baseline, 5-year, and 10-year follow-up). We assessed hearing sensitivity through pure-tone audiometry (PTA, averaged thresholds of 0.5, 1, 2, 4 kHz of the better ear), higher-order auditory processing as word recognition in competing message (WRCM) using the Northwestern University 6 word list in the better ear, and cognition through trail-making test performance (TMT). Linear mixed-effects models and linear regression models were used to determine associations over time and to what extent these measures influence each other over time.Results The longitudinal decline between all functions was associated with the strongest relationships between PTA and WRCM. The effect of baseline PTA on WRCM 10 years later (standardized ss = -.30) was almost twice as big as the effect of baseline WRCM on PTA 10 years later (standardized ss = -.18). The effect of baseline WRCM on TMT 10 years later and vice versa were small (standardized ss = -.05). No directional relationship between PTA and TMT was identified (standardized ss