Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis
Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis
复制标题
沉默信息调节器 1 的血清水平与急性胰腺炎持续性器官衰竭的关联。
DOI：
10.1007/s10620-019-05647-x
复制
发表时间：
2019-11-01
影响因子：
3.1
通讯作者：
Xia, Liang
中科院分区：
文献类型：
--
作者：
Chen, Jie;Wan, Jianhua;Xia, Liang
背景/目的早期评估是充分和全面治疗急性胰腺炎（AP）的关键因素。沉默信息调节因子1（SIRT 1）在炎症反应中起重要作用。目的探讨血清SIRT 1与AP患者持续性器官衰竭（POF）的关系。所有113例患者的血液样本收集后的第一个早晨入院的AP症状发作的48小时内。结果HCs组、轻度AP组、中重度AP组和重度AP组血清SIRT 1蛋白水平分别为1495.7 ± 185.9、2098.3 ± 153.6、2498.4 ± 198.2和3674.3 ± 170.8 pg/ml; HC组与AP组比较差异有显著性（P < 0.05）。POF患者血清SIRT 1水平较非POF患者明显升高（P < 0.05）。当SIRT 1浓度的截断值为4065.4pg/ml时，SIRT 1预测POF的受试者工作特征曲线下面积（AUC）为0.825（95% CI 0.744-0.906），敏感性为61.4%，特异性为92.8%。SIRT 1与床旁重症急性胰腺炎指数（BISAP）联合预测POF的AUC为0.931（95% CI 0.882，0.980）。将血清SIRT 1浓度与BISAP相结合可提高预测结果的能力。
Background/Aims Early assessment is a key factor for adequate and comprehensive treatment of acute pancreatitis (AP). Silent information regulator 1 (SIRT1) plays an important role in inflammation. The aim was to explore the relationship between serum SIRT1 and persistent organ failure (POF) in patients with AP.Methods Thirty-seven healthy controls (HCs) and 113 patients with AP were recruited for this study. All 113 patients whose blood samples were collected on the first morning after admission were within 48 h of the onset of AP symptoms. The concentration of serum SIRT1 protein was determined by enzyme-linked immunosorbent assay.Results The serum SIRT1 protein levels were 1495.7 +/- 185.9, 2098.3 +/- 153.6, 2498.4 +/- 198.2, and 3674.3 +/- 170.8 pg/ml in the HCs, mild AP, moderately severe AP, and severe AP groups, respectively. Obvious differences were observed between HCs and patients with AP (P < 0.05). Significant increases were observed in SIRT1 concentrations in patients with POF compared with non-POF patients (P < 0.05). When the cut-off of the SIRT1 concentration was 4065.4 pg/ml, the serum SIRT1 concentration had an area under the curve (AUC) of the receiver operating characteristic curve of 0.825 (95% CI 0.744-0.906) for predicting POF, with a sensitivity of 61.4% and specificity of 92.8%. Combining serum SIRT1 and bedside index for severity acute pancreatitis (BISAP) achieved 0.931 (95% CI 0.882, 0.980) of AUC for the predication of POF.Conclusions High serum SIRT1 levels may serve as an early predictive marker for POF. Combining the serum SIRT1 concentration with BISAP increased the ability to predict outcomes.