The role of the anterior prefrontal cortex in human cognition
The role of the anterior prefrontal cortex in human cognition
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DOI：
10.1038/20178
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发表时间：
1999-05-13
期刊：
影响因子：
64.8
通讯作者：
Grafman, J
中科院分区：
文献类型：
--
作者：
Koechlin, E;Basso, G;Grafman, J
复杂的问题解决和计划涉及额叶的最前部，包括额极前额叶皮层（FPPC）（1-6），与其他灵长类动物相比，人类的FPPC特别发达（7，8）。然而，这一区域在人类认知中的具体作用却知之甚少。在这里，我们显示使用功能性磁共振成像，在FPPC单独的双边区域被选择性激活时，受试者必须牢记一个主要目标，同时执行并发（子）目标。无论是随着时间的推移记住一个目标（工作记忆），还是在不同目标之间连续分配注意力资源（双重任务表现），都不能激活这些区域。我们的研究结果表明，FPPC选择性地介导人类的能力，在脑海中的目标，同时探索和处理次要目标，一般需要在规划和推理的过程。
Complex problem-solving and planning involve the most anterior part of the frontal lobes including the fronto-polar prefrontal cortex (FPPC)(1-6), which is especially well developed in humans compared with other primates(7,8). The specific role of this region in human cognition, however, is poorly understood. Here we show using functional magnetic resonance imaging, that bilateral regions in the FPPC alone are selectively activated when subjects have to keep in mind a main goal while performing concurrent (sub)goals. Neither keeping in mind a goal over time (working memory) nor successively allocating attentional resources between alternative goals (dual-task performance) could by themselves activate these regions. Our results indicate that the FPPC selectively mediates the human ability to hold in mind goals while exploring and processing secondary goals, a process generally required in planning and reasoning.