Glucose flux in relation to energy expenditure in malnourished patients with and without cancer during periods of fasting and feeding.
Glucose flux in relation to energy expenditure in malnourished patients with and without cancer during periods of fasting and feeding.
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发表时间：
1984-04
期刊：
影响因子：
11.2
通讯作者：
E. Edén;S. Edström;K. Bennegȧrd;T. Scherstén;K. Lundholm
中科院分区：
文献类型：
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作者：
E. Edén;S. Edström;K. Bennegȧrd;T. Scherstén;K. Lundholm
研究了8名营养不良的癌症患者和7名营养不良的非癌症患者的葡萄糖动力学、能量代谢和氮平衡。通过单次注射[6- 3 H]葡萄糖和[U-14 C]葡萄糖测量葡萄糖通量。能量消耗通过间接量热法测量。每例患者在禁食过夜后和持续胃内输注配方饮食期间进行研究。癌症患者空腹时葡萄糖通量升高，相当于其每日自发葡萄糖摄入量的42%。与对照组相比，癌症患者中至少有一半的高通量是由于过夜禁食后葡萄糖碳的再循环增加。进食使癌症患者和对照组患者的总葡萄糖流量增加了一倍。癌症组的再循环没有变化，而对照组在进食过程中消失。在癌症患者中，在禁食和进食期间，葡萄糖通量的增加伴随着正常的静息能量消耗。与对照组相比，癌症患者中与能量消耗相关的葡萄糖通量加倍，并且进食癌症患者中的葡萄糖通量与葡萄糖输注速率相似，这表明葡萄糖的内源性产生未被抑制。癌症和对照组患者达到了相当的正能量和氮平衡，允许他们的总热量摄入。我们的研究结果表明，癌症患者似乎具有特征性的葡萄糖需求增加，这有助于他们在禁食时减肥。这种升高的葡萄糖通量的能量消耗可以解释，作为最大估计，每30天损失约0.9 kg的体脂。
Glucose dynamics, energy metabolism, and nitrogen balance were studied in eight malnourished cancer patients and seven malnourished patients without cancer. Glucose flux was measured by single injection of [6-3H]glucose and [U-14C]glucose. Energy expenditure was measured by indirect calorimetry. Each patient was studied after an overnight fast and during constant gastric infusion of a formula diet. Cancer patients had elevated glucose flux when fasting, corresponding to 42% of their spontaneous daily intake of glucose. At least one-half of the elevated flux in cancer patients compared with controls was due to increased recycling of glucose carbon after an overnight fast. Feeding doubled the total glucose flux in both cancer and control patients. The recycling was unchanged in the cancer group and disappeared in the controls during feeding. The increased glucose flux in cancer patients was concomitant with normal resting energy expenditure during periods of both fasting and feeding. Glucose flux in relation to energy expenditure was doubled in cancer patients compared to controls, and the glucose flux in fed cancer patients was similar to the rate of glucose infusion, which shows that the endogenous production of glucose was not inhibited. Cancer and control patients reached a comparable positive energy and nitrogen balance, allowing for their overall caloric intake. Our results show that cancer patients seem to have a characteristically increased glucose demand, which contributes to their weight loss when fasting. The energy drain by this elevated glucose flux can explain, as a maximum estimate, a loss of about 0.9 kg of body fat per 30-day period.