Solitary fibrous tumor of the middle ear: Immunoexpression of NAB2-STAT6 fusion gene
Solitary fibrous tumor of the middle ear: Immunoexpression of NAB2-STAT6 fusion gene
复制标题
中耳孤立性纤维瘤：NAB2-STAT6融合基因的免疫表达
DOI：
10.1016/j.xocr.2021.100345
复制
发表时间：
2021
影响因子：
--
通讯作者：
Suzuki Masashi
中科院分区：
文献类型：
--
作者：
Tateyama Kaori;Hamada Masashi;Kawano Toshiaki;Kusaba Takahiro;Daa Tsutomu;Suzuki Masashi
目的报告1例罕见的左侧中耳孤立性纤维瘤（SFT）的临床和病理表现，患者女，51岁，因左侧听力下降和耳痛5个月就诊。术前耳镜检查发现一个搏动的蓝色肿块，导致我们诊断为鼓室球瘤。采用面神经隐窝入路乳突切除术将肿瘤完全切除。组织学显示细胞核质比低，具有均匀的短梭形和圆形，染色密集的细胞核。免疫组化显示bcl-2和STAT 6阳性。对手术切除的标本进行嵌合基因搜索，检测到NAB 2-STAT 6融合基因。患者最终被诊断为SFT。在36个月的计算机断层扫描follow-up. ConclusionsExtrapolarial SFT经常被报道，但没有SFT在中耳产生的文献报道。中耳的SFT与血管球瘤有相似的临床表现，因为它们是富血管的肿瘤性病变。NAB 2-STAT 6融合基因的免疫组化表达对SFT的诊断有一定的意义。
ObjectiveTo describe the clinical and pathological findings of a rare case of a solitary fibrous tumor (SFT) arising in the left middle ear, treated with middle ear surgery.PatientA 51-year-old woman presented with a 5-month history of left hearing loss and otalgia. Preoperative otoscopic findings revealed a pulsating blue mass, leading us to the diagnosis of a glomus tympanicum tumor. The tumor was completely resected with mastoidectomy using the facial recess approach. Histopathology showed cells with a low nuclear-to-cytoplasm ratio, having a uniform short spindle-shaped and circular, densely stained nucleus. By immunostaining, the cells werebcl-2andSTAT6-positive. Using a chimeric gene search of the surgically resected specimen, theNAB2-STAT6fusion gene was detected. The patient was finally diagnosed with SFT. No recurrence was found in the 36-month computed tomography follow-up.ConclusionsExtrapleural SFTs have often been reported but no SFT arising in the middle ear have ever been reported in the literature. The SFT of the middle ear had similar clinical manifestations as the glomus tumor in that they are hypervascular neoplastic lesions. Immunoexpression of theNAB2-STAT6fusion gene were useful for the diagonosis of SFT.
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影响因子：
--
作者：
Yoon CM;Cho JM;Lim KR;Kim SK;Kim SJ;Lee KC
通讯作者：
Lee KC
影响因子：
1.7
作者：
Sanna, Mario;Fois, Paolo;Bacciu, Andrea
通讯作者：
Bacciu, Andrea
内镜改良内侧上颌骨切除术及其对泪囊和鼻泪管孤立性纤维瘤的局限性。
DOI：
10.1016/j.anl.2016.07.010
发表时间：
2017
期刊：
Auris, nasus, larynx
影响因子：
--
作者：
Munehito Moriyama;S. Kodama;T. Hirano;Masashi Suzuki
通讯作者：
Masashi Suzuki
影响因子：
1.6
作者：
K. Yammine;H. Nasser;U. Hadi;M. Natout;V. Najjar;C. Tayar
通讯作者：
C. Tayar
影响因子：
1.7
作者：
Izumaru, S;Yoshida, Y;Nakashima, T
通讯作者：
Nakashima, T