Quantitative assessment of neuropathic pain.
Quantitative assessment of neuropathic pain.
复制标题
DOI：
10.1007/s11916-001-0078-y
复制
发表时间：
2001-04-01
影响因子：
3.7
通讯作者：
Greenspan, J D
中科院分区：
文献类型：
--
作者：
Greenspan, J D
定量感觉测试（QST）是指一组允许对躯体感觉功能进行定量测量的方案。几个协议评估知觉阈值，而其他评估感知阈值以上的刺激。每个协议都有自己的优点和缺点，但必须始终在准确性（使用较长的协议）和方便性（使用较短的协议）之间进行权衡。在评估神经性疼痛患者时，人们对阳性和阴性感觉症状都感兴趣。QST研究，使用神经性疼痛患者或健康志愿者谁已呈现暂时性痛觉过敏，已证明疼痛异常可以是特定的方式。各种疼痛异常可以相互独立地存在，这一事实表明（至少部分地）不同的神经病理过程对每一种异常负责。目前的研究表明，外周敏化和中枢敏化在这些异常疼痛条件中发挥作用，并且正在积极研究精确的神经病理机制。
Quantitative sensory testing (QST) refers to a group of protocols that allows for quantitative measures of somesthetic function. Several protocols evaluate perceptual threshold, whereas others evaluate perception of stimuli above threshold. Each protocol has its own advantages and disadvantages, but one must always weigh a trade-off between accuracy (with longer protocols) and expediency (with shorter protocols). In assessing patients with neuropathic pain, one is interested in both positive and negative sensory symptoms. QST studies, using either neuropathic pain patients or healthy volunteers who have been rendered temporarily hyperalgesic, have demonstrated that pain abnormalities can be modality specific. The fact that various pain abnormalities can exist independently of each other suggests that (at least partially) different neuropathologic processes are responsible for each one. Current research suggests that both peripheral sensitization and central sensitization play a role in these abnormal pain conditions, and identification of precise neuropathologic mechanisms is under active investigation.