Exocrine and Endocrine Pancreatic Function in 21 Patients Suffering from Autoimmune Pancreatitis before and after Steroid Treatment
Exocrine and Endocrine Pancreatic Function in 21 Patients Suffering from Autoimmune Pancreatitis before and after Steroid Treatment
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DOI：
10.1159/000265945
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发表时间：
2010-01-01
期刊：
影响因子：
3.6
通讯作者：
Vantini, Italo
中科院分区：
文献类型：
--
作者：
Frulloni, Luca;Scattolini, Chiara;Vantini, Italo
背景/目的：自身免疫性胰腺炎（AIP）对类固醇治疗反应迅速且显著。本研究的目的是评估AIP患者在类固醇治疗前后的胰腺外分泌和内分泌功能。患者和方法：对2006年至2008年间诊断为AIP的21例患者（男性13例，女性8例，平均年龄43±16.5岁）的粪便弹性蛋白酶1和糖尿病在类固醇治疗前和停药1个月内进行评估。结果：临床发病时，粪便弹性蛋白酶1为107 +/- 126 μ g/g。13例（62%）表现为严重胰功能不全（大便200 μ g/g）。在使用类固醇之前，有5例（24%）患者被诊断为糖尿病，这些患者的粪便弹性蛋白酶1水平都很低(
Background/Aim: Autoimmune pancreatitis (AIP) responds rapidly and dramatically to steroid therapy. The aim of this study was to evaluate pancreatic exocrine and endocrine function in patients suffering from AIP both before and after steroid therapy. Patients and Methods: Fecal elastase 1 and diabetes were evaluated before steroid therapy and within 1 month of its suspension in 21 patients (13 males and 8 females, mean age 43 +/- 16.5 years) diagnosed as having AIP between 2006 and 2008. Results: At clinical onset, fecal elastase 1 was 107 +/- 126 mu g/g stool. Thirteen patients (62%) showed severe pancreatic insufficiency (200 mu g/g stool). Before steroids, diabetes was diagnosed in 5 patients (24%), all of whom had very low levels of fecal elastase 1 (