EXPLORATION OF THE GENES RESPONSIBLE FOR UNLIMITED PROLIFERATION OF IMMORTALIZED LUNG FIBROBLASTS
EXPLORATION OF THE GENES RESPONSIBLE FOR UNLIMITED PROLIFERATION OF IMMORTALIZED LUNG FIBROBLASTS
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DOI：
10.1080/01902140802221912
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发表时间：
2008-01
影响因子：
1.7
通讯作者：
K. Hiyama;K. Tanimoto;Y. Nishimura;M. Tsugane;I. Fukuba;Y. Sotomaru;E. Hiyama;M. Nishiyama
中科院分区：
文献类型：
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作者：
K. Hiyama;K. Tanimoto;Y. Nishimura;M. Tsugane;I. Fukuba;Y. Sotomaru;E. Hiyama;M. Nishiyama
肺成纤维细胞增殖的调控机制尚不清楚。为了阐明其中的关键分子，作者在此通过端粒酶逆转录酶基因转染建立了具有延长寿命的非转化肺成纤维细胞系/株。比较它们的表达谱，发现51个基因可能是调节肺成纤维细胞增殖的候选基因。这组来源相同但增殖能力不同的成纤维细胞株可能成为研究肺成纤维细胞生长调控的有用模型细胞，本研究中探索的候选基因可能提供肺纤维化的生物标志物或治疗靶点。
Regulation mechanism of lung fibroblast proliferation remains unknown. To elucidate the key molecules in it, the authors here established mortal and immortal nontransformed lung fibroblast cell line/strains with elongated life span by telomerase reversetranscriptase gene transfection. Comparing the expression profiles of them, 51 genes were explored to be the candidates responsible for regulation of cellular proliferation of lung fibroblasts. This set of fibrobrast strains of same origin with different proliferative capacities may become useful model cells for research on lung fibroblast growth regulation and the candidate genes explored in this study may provide biomarkers or therapeutic targets of pulmonary fibrosis.