Anti-influenza virus activity of two extracts of the blackcurrant (Ribes nigrum L.) from New Zealand and Poland.
Anti-influenza virus activity of two extracts of the blackcurrant (Ribes nigrum L.) from New Zealand and Poland.
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DOI：
10.5387/fms.59.35
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发表时间：
2013-01-01
影响因子：
0.8
通讯作者：
Suzutani, Tatsuo
中科院分区：
文献类型：
--
作者：
Ikuta, Kazufumi;Mizuta, Katsumi;Suzutani, Tatsuo
研究了黑加仑（Ribes nigrum L.）来自新西兰和波兰的4株流感病毒（IFV）通过抑制病毒吸附; 2009-2010年大流行流感（IFV-AH 1 pdm）、香港流感（IFV-AH 3）、磷酸奥司他韦耐药俄罗斯流感（IFV-AH 1 tamr）和B型流感病毒（IFV-B）。通过抑制病毒在细胞表面的吸附（吸附抑制试验）来评价黑加仑或蓝莓提取物对病毒粒子感染性的抑制作用。来自新西兰和波兰的3%的黑加仑提取物溶液足以消毒超过一半的IFV-AH 1 pdm和IFV-B，并且来自两个地区的10%的溶液完全消毒所有IFV菌株。我们以前的研究表明，黑醋栗的抗病毒作用根据病毒种类而不同。在这里，我们表明，虽然黑加仑的抗病毒效果略有不同的病毒株从一个物种，黑加仑提取物可以消毒所有4 IFV株，我们检查。黑加仑提取物显示出一定的潜力，作为一种消毒剂和防腐剂，以防止IFV感染。
We investigated the inhibitory effect of extracts of blackcurrant (Ribes nigrum L.) from New Zealand and Poland on 4 strains of influenza virus (IFV) by the inhibition of virus adsorption; pandemic flu from 2009-2010 (IFV-AH1pdm), Hong Kong flu (IFV-AH3), oseltamivir phosphate-resistant Russian flu (IFV-AH1tamr) and influenza virus type B (IFV-B). The inhibitory effect of the extracts of blackcurrant or blueberry on the infectivity of the virion were evaluated by the inhibition of virus adsorption on the cell surface (adsorption-inhibitory assay). Three percent solutions of the blackcurrant extracts from New Zealand and Poland were enough to disinfect more than half of IFV-AH1pdm and IFV-B, and 10% solutions from both regions disinfected all IFV strains completely. Our previous study showed that the antiviral effect of the blackcurrant differed according to viral species. Here we showed that although the antiviral effect of Blackcurrant was slightly different within viral strains from one species, the extract of Blackcurrant could disinfect all of 4 IFV strains we examined. The extracts of blackcurrant showed definite potential for use as a disinfectant and antiseptic agent to prevent IFV infection.