Sparse activity of identified dentate granule cells during spatial exploration
Sparse activity of identified dentate granule cells during spatial exploration
复制标题
DOI：
10.7554/elife.20252
复制
发表时间：
2016-10-03
期刊：
影响因子：
7.7
通讯作者：
Burgalossi, Andrea
中科院分区：
文献类型：
--
作者：
Diamantaki, Maria;Frey, Markus;Burgalossi, Andrea
在齿状回中，颗粒细胞是空间记忆回路的重要组成部分，它具有形态多样性，在行为过程中表现出不同的活动特征。为了解决结构与功能的关系，我们在自由活动的大鼠中以单细胞方式记录并标记单个GC。我们发现绝大多数神经元在探索过程中是沉默的。大多数活跃的GC表现出特征性的尖峰波形，发射率低，并表现出空间活动。初级树突参数足以将神经元高精度地分类为活跃或沉默。因此，我们的数据支持在齿状回的稀疏编码方案，并提供了一个可能的GC人口之间的结构和功能异质性之间的联系。
In the dentate gyrus a key component of spatial memory circuits granule cells (GCs) are known to be morphologically diverse and to display heterogeneous activity profiles during behavior. To resolve structure function relationships, we juxtacellularly recorded and labeled single GCs in freely moving rats. We found that the vast majority of neurons were silent during exploration. Most active GCs displayed a characteristic spike waveform, fired at low rates and showed spatial activity. Primary dendritic parameters were sufficient for classifying neurons as active or silent with high accuracy. Our data thus support a sparse coding scheme in the dentate gyrus and provide a possible link between structural and functional heterogeneity among the GC population.