Oxidative stress, oxidative balance score, and hypertension among a racially diverse population.
Oxidative stress, oxidative balance score, and hypertension among a racially diverse population.
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DOI：
10.1016/j.jash.2015.05.014
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Lakkur S
中科院分区：
文献类型：
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作者：
Annor FB;Goodman M;Okosun IS;Wilmot DW;Il'yasova D;Ndirangu M;Lakkur S
高血压是几种血管疾病的危险因素。有证据表明，氧化应激（OS）在其病理生理中起着重要作用。人体研究显示了不一致的结果，根据OS生物标志物和研究人群而有所不同。在一个种族多样的人群中，检查（1）血压或高血压与OS的四个标志物之间的关系，以及（2）血压或高血压与氧化平衡评分（OBS）之间的关系。使用数据（n = 317）从种族，压力和高血压的横断面研究，一个OBS构建从各种措施的促氧化剂和抗氧化剂的暴露。通过四种生物标志物评估OS：荧光氧化产物、F2-异前列烷、线粒体DNA拷贝数和γ-生育酚。多变量线性和逻辑回归分析用于估计相关性。高血压和OS标志物之间的校正相关性均无统计学显著性。调整研究协变量后，OBS与高血压呈负相关。具有较高的OBS的人具有较低的高血压几率;然而，OS标记物和血压之间的关系的证据仍然不令人信服。
Hypertension is a risk factor for several vascular diseases. Evidence suggests that oxidative stress (OS) plays a significant role in its pathophysiology. Human studies have shown inconsistent results, varying based on the OS biomarker and study population. In a racially diverse population, examine the association between: (1) blood pressure or hypertension and four markers of OS and (2) blood pressure or hypertension and oxidative balance score (OBS). Using data (n = 317) from the cross-sectional study on race, stress, and hypertension, an OBS was constructed from various measures of pro-oxidant and antioxidant exposures. OS was assessed by four biomarkers: fluorescence oxidative products, F2-isoprostanes, mitochondrial DNA copy number, and gamma tocopherol. Multivariate linear and logistic regression analyses were used to estimate the associations of interest. None of the adjusted associations between hypertension and OS markers was statistically significant. OBS was inversely associated with hypertension after adjusting for study covariates. Persons with higher OBS have lower odds of having hypertension; however, the evidence on the relationship between OS markers and blood pressure remains unconvincing.