TIME COURSE OF EEG POWER-DENSITY DURING LONG SLEEP IN HUMANS
TIME COURSE OF EEG POWER-DENSITY DURING LONG SLEEP IN HUMANS
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DOI：
10.1152/ajpregu.1990.258.3.r650
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发表时间：
1990-03-01
影响因子：
--
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
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作者：
DIJK, DJ;BRUNNER, DP;BORBELY, AA
在基线条件下记录9名受试者的睡眠情况，包括习惯性就寝时间（先前清醒16小时，2300小时熄灯）和从睡眠剥夺中恢复的阶段提前就寝时间（先前清醒36小时，1900小时熄灯）。所有受试者的阶段前恢复性睡眠持续时间均为12h。睡眠脑电图（EEG）频谱分析显示，非快速眼动（NREM）睡眠的慢波活动（SWA; 0.75 ~ 4.5 Hz）在移位恢复期的前两个NREM- rem睡眠周期中显著增强。睡眠阶段3和4（慢波睡眠）和SWA分别在基线睡眠和恢复性睡眠的前3个和4个NREM-REM周期中单调下降。基线睡眠和恢复期睡眠的时间过程可以用一个水平渐近线的指数下降函数来充分描述。结果与睡眠调节的双过程模型一致，该模型假设SWA随先前清醒时间的延长而上升，随先前睡眠时间的延长而呈指数下降。我们的结论是，目前的数据并不能提供12.5小时的深度非快速眼动睡眠依赖睡眠节奏的证据。
In nine subjects sleep was recorded under base-line conditions with a habitual bedtime (prior wakefulness 16 h; lights off at 2300 h) and during recovery from sleep deprivation with a phase-advanced bedtime (prior wakefulness 36 h; lights off at 1900 h). The duration of phase-advanced recovery sleep was >12 h in all subjects. Spectral analysis of the sleep electroencephalogram (EEG) revealed that slow-wave activity (SWA; 0.75-4.5 Hz) in non-rapid-eye-movement (NREM) sleep was significantly enhanced during the first two NREM-REM sleep cycles of displaced recovery sleep. The sleep stages 3 and 4 (slow-wave sleep) and SWA decreased monotonically over the first three and four NREM-REM cycles of, respectively, base-line and recovery sleep. The time course of SWA in base-line and recovery sleep could be adequately described by an exponentially declining function with a hortizontal asymptote. The results are in accordance with the two-process model of sleep regulation in which it is assumed that SWA rises as a function of the duration of prior wakefulness and decreases exponentially as a function of prior sleep. We conclude that the present data do not provide evidence for a 12.5-h sleep-dependent rhythm of deep NREM sleep.