Trend in cumulative cases and mortality rate among visceral leishmaniasis patients in Eastern Sudan: a 14-year registry, 2002-2015
Trend in cumulative cases and mortality rate among visceral leishmaniasis patients in Eastern Sudan: a 14-year registry, 2002-2015
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DOI：
10.1016/j.ijid.2016.08.021
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发表时间：
2016-10-01
影响因子：
8.4
通讯作者：
Ali, AbdelAziem A.
中科院分区：
文献类型：
--
作者：
Adama, Gamal K.;Ali, Khalid M.;Ali, AbdelAziem A.
背景：利什曼病是世界上被忽视的传染病之一。这种疾病主要影响社会经济水平较低的人群，主要集中在发展中国家。方法：本研究的目的是调查苏丹东部内脏利什曼病(VL)的累计病例数、病死率以及发病率和死亡率的趋势。通过对加达里夫州卫生部管理的数据库的分析，进行了一项回顾性描述性研究，其中包括所有VL病例。结果：在14年的研究期间(2002-2015)，Gadarif州共登记了51773名VL患者，临床和实验室证据均已证实。与2011-2015年的最后5年相比，VL在2003-2005年间的趋势要高得多。死亡率最高的是2002年(4.8%)，2014年(1.1%)和2015年(1.7%)有所下降。农村居民与VL相关的死亡在统计学上是相关的(p=0.021)。结论：本研究显示在苏丹东部VL累积病例数很高。死亡率在农村居民中最高，在过去5年中有所下降。因此，在健康教育和实施预防措施方面需要立即采取干预措施，特别是针对居住在农村地区的人。(C)2016年提交人。爱思唯尔有限公司代表国际传染病学会出版。
Background: Leishmaniasis is one of the neglected infectious diseases of the world. This disease largely affects individuals of low socio-economic level, mainly in developing countries.Methods: The aim of this study was to investigate the cumulative number of cases, case fatality rate, and trend in incidence and mortality rate of visceral leishmaniasis (VL) in Eastern Sudan. A retrospective descriptive study was performed through analysis of the database managed by the Ministry of Health in Gadarif State, which includes all cases of VL.Results: Over the 14-year study period (2002-2015), a total of 51 773 patients were registered in Gadarif State with clinical and laboratory evidence of proven VL. The trend in VL was considerably higher over the years 2003-2005 as compared to the last 5 years of 2011-2015. The highest fatality rate was observed in 2002 (4.8%) and it had declined in 2014 (1.1%) and 2015 (1.7%). Rural residence was statistically associated with death related to VL (p = 0.021).Conclusions: This study showed a high number of cumulative cases of VL in Eastern Sudan. The fatality rate was found to be highest among rural residents and has declined in the last 5 years. Thus immediate interventions are needed in terms of health education and the implementation of preventive measures, with a specific focus on people residing in rural areas. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.