Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.
Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.
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DOI：
10.18632/aging.100882
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Haynes L
中科院分区：
文献类型：
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作者：
Bartley JM;Pan SJ;Keilich SR;Hopkins JW;Al-Naggar IM;Kuchel GA;Haynes L
虽然流感病毒只感染呼吸系统，但在感染期间通常会出现肌痛。除了住院和死亡的风险更大外，老年人更有可能在流感感染后发生残疾;然而，这种关系尚未得到充分研究。我们假设，在流感的挑战，老化将与功能障碍，以及上调骨骼肌炎症和萎缩基因。感染的年轻和老年小鼠表现出活动能力下降和步态动力学改变。这些下降在后肢和老年小鼠中更为突出。在流感感染期间，老年小鼠骨骼肌中参与炎症、肌肉萎缩和蛋白水解的基因表达增加，峰值升高并延长。感染也降低了表达的肌肉质量和肌生成组件的正调节剂在更大程度上在老年小鼠。基因表达与流感引起的体重减轻相关，尽管证据并不支持直接的肌肉感染。总的来说，流感导致移动障碍，诱导炎症和肌肉降解基因，并下调肌肉的正调节因子。这些影响随着年龄的增长而增强和延长，在老年人中流感感染，恢复能力下降和残疾风险增加之间提供了分子联系。
Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized that upon challenge with influenza, aging would be associated with functional impairments, as well as upregulation of skeletal muscle inflammatory and atrophy genes. Infected young and aged mice demonstrated decreased mobility and altered gait kinetics. These declines were more prominent in hind limbs and in aged mice. Skeletal muscle expression of genes involved in inflammation, as well as muscle atrophy and proteolysis, increased during influenza infection with an elevated and prolonged peak in aged mice. Infection also decreased expression of positive regulators of muscle mass and myogenesis components to a greater degree in aged mice. Gene expression correlated to influenza-induced body mass loss, although evidence did not support direct muscle infection. Overall, influenza leads to mobility impairments with induction of inflammatory and muscle degradation genes and downregulation of positive regulators of muscle. These effects are augmented and prolonged with aging, providing a molecular link between influenza infection, decreased resilience and increased risk of disability in the elderly.