N-DOCOSANOL - BROAD-SPECTRUM ANTIVIRAL ACTIVITY AGAINST LIPID-ENVELOPED VIRUSES
N-DOCOSANOL - BROAD-SPECTRUM ANTIVIRAL ACTIVITY AGAINST LIPID-ENVELOPED VIRUSES
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DOI：
10.1111/j.1749-6632.1994.tb38949.x
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
MCFADDEN, R
中科院分区：
文献类型：
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作者：
KATZ, DH;MARCELLETTI, JF;MCFADDEN, R
Earlier work of others demonstrated the existence of virucidal activity of medium length (10-12 carbons) saturated alcohols; such activity was complicated by coexisting toxicity, and appeared to be lost as chain length increased up to 18 carbons or longer.'Recently, we re-examined alcohol compounds for activity against various viruses, specifically focusing on higher chain lengths with the aim of identifying potential broad spectrum anti-viral activity among such compounds. This work confirmed that saturated alcohols of 18 carbons or longer, like the 22-carbon compound n-docosanol, exhibit very potent anti-viral activity both in vitro and in~ ivo.'-'n-Docosanol is derived from hydrogenation of fatty acid mixtures extracted from various plant sources or fossil fuels, yielding corresponding fatty alcohol mixtures from which n-docosanol can be purified by fractional vacuum distillation. The purified compound is highly lipophilic and extremely insoluble, prompting conventional wisdom to dictate that this molecule and others like it should be biologically inert. Our previous and those presented herein document that conventional wisdom is absolutely wrong in this case. Thus, appropriately formulated n-docosanol exhibits broad-spectrum anti-viral activity with apparent specificity for lipid-enveloped viruses including, among others, types 1 and 2 herpes simplex and respiratory syncytial murine and human cytomegalovirus, and certain retroviruses (unpublished), but no activity against the non-enveloped poliovirus. Importantly, unlike alcohols of 20 carbons or less, which exhibit zyxwvutsrqpo
