SOMATOSENSORY EVOKED-POTENTIALS TO FINGER STIMULATION IN HEALTHY OCTOGENARIANS AND IN YOUNG-ADULTS - WAVE FORMS, SCALP TOPOGRAPHY AND TRANSIT TIMES OF PARIETAL AND FRONTAL COMPONENTS
SOMATOSENSORY EVOKED-POTENTIALS TO FINGER STIMULATION IN HEALTHY OCTOGENARIANS AND IN YOUNG-ADULTS - WAVE FORMS, SCALP TOPOGRAPHY AND TRANSIT TIMES OF PARIETAL AND FRONTAL COMPONENTS
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DOI：
10.1016/0013-4694(80)90007-3
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
CHERON, G
中科院分区：
文献类型：
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作者：
DESMEDT, JE;CHERON, G
本文对25名青年人和19名健康老年人的额、顶叶体感诱发电位（SEP）、脊髓SEP和感觉神经动作电位进行了研究。肢体温度为36 - 37 ℃。C. SEP波形和详细的头皮地形图的受试者之间的变化有助于描绘几个真正的SEP成分，即P25，N32和N40，在中央前头皮网站。顶叶W型（P30-N35-P45）在年轻人中仅占48%，但在老年人中占90%。所有顶叶成分的大小显着增加，在老年人，这与减少脊髓SEP和感觉神经电位。中央前SEP成分维持（P25）或减少（N32）。初级传入神经元的衰老速度（CV [传导速度]每年降低约0.16 m/s）似乎快于第二或第三传入神经元（从脊髓进入到中央后皮质的传输时间或平均中央CV无显著变化）。SEP在中央裂前、后的头皮记录有明显差异。相反，深偶极子假说的SEP记录前或postcentralized不是镜像，并表现出单独的非一致的受试者间的变异。行波假说也被拒绝，因为SEP分量呈现在其头皮区域内稳定的峰值潜伏期。在顶叶和额叶皮层模块的顺序激活，部分通过证明皮质-皮质轴突连接，也可能通过丘脑-皮质的预测，可以产生连续的SEP组件。皮层发生器的SEP组件似乎是相似的，虽然它们的相对强度的变化和不同组件之间的渡越时间显着增加。
Frontal and parietal SEP [somatosensory evoked potential] to electrical stimulation of fingers were studied in conjunction with the spinal SEP and sensory nerve action potentials in 25 young adults and 19 healthy octogenarians. Limb temperatures were 36-37.degree. C. Intersubject variations of SEP wave forms and detailed scalp topography helped delineate several genuine SEP components, namely the P25, N32 and N40, at precentral scalp sites. The parietal W pattern (P30-N35-P45) was recorded in only 48% of the young, but 90% of the old subjects. All parietal components were significantly increased in size in the old, which contrasts with the reduced spinal SEP and sensory nerve potentials. The precentral SEP components were either maintained (P25) or reduced (N32). The primary afferent neurons appeared to age at a faster rate (CV [conduction velocity] reduced about 0.16 m/s per yr) than the 2nd or 3rd afferent neurons (no significant change in transit time from spinal entry to postcentral cortex or in mean central CV). The scalp recorded SEP were quite different in front of or behind the central fissure. Contrary to the deep dipole hypothesis the SEP recorded pre- or postcentrally were not mirror images and exhibited separate non-congruent intersubject variabilities. The traveling wave hypothesis was also rejected since the SEP components presented peak latencies that were stable within their scalp territory. The sequential activation of cortical modules in parietal and frontal areas, in part through demonstrated cortico-cortical axonal connections and possibly also through thalamo-cortical projections, could generate successive SEP components. The cortical generators of SEP components appeared to be similar in the octogenarians although their relative strengths changed and transit times between different components significantly increased.