Impact of adjuvant breast cancer chemotherapy on fatigue, other symptoms, and quality of life.
Impact of adjuvant breast cancer chemotherapy on fatigue, other symptoms, and quality of life.
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DOI：
10.1188/06.onf.e18-e26
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发表时间：
2006-01-01
影响因子：
1.9
通讯作者：
Cetak, Melissa A
中科院分区：
文献类型：
--
作者：
Byar, Katherine L;Berger, Ann M;Cetak, Melissa A
目的：确定化疗期间和化疗后长达一年的疲劳、其他身体症状和心理症状的差异及其与生活质量（QOL）的关系。设计：纵向，描述性设计嵌入一个试点干预研究。地点：中西部城市肿瘤诊所和患者之家。样本：25名白人女性，年龄40-65岁（-X = 54.3）， I期或II期乳腺癌接受基于阿霉素的化疗。方法：在每次治疗前后分别填写Piper疲劳量表、医院焦虑抑郁量表、症状体验量表、医疗结局研究简表一般健康调查；末次治疗后30、60、90天；第一次治疗后一年。主要研究变量：疲劳、生理和心理症状、生活质量。研究结果：在治疗期间，疲劳水平中等强度，随着时间的推移显着下降。睡眠障碍和疼痛是最常见、最严重和最令人痛苦的其他身体症状。焦虑在基线时最高，抑郁在第四次化疗期间最高。在治疗期间的某些时间和治疗后的持续时间内，疲劳与其他生理和心理症状相关。在几个方面，较高的疲劳程度与较低的生活质量相关。结论：疲劳与治疗期间和治疗后波动的其他生理和心理症状有关。更高的疲劳会影响生活质量。护理意义：针对原发性或聚集性症状的干预措施可以减少辅助化疗对疲劳、其他症状和生活质量的影响。
PURPOSE/OBJECTIVES: To identify differences in fatigue, other physical symptoms, and psychological symptoms and their relationship to quality of life (QOL) during chemotherapy and as long as one year after.DESIGN: Longitudinal, descriptive design embedded in a pilot intervention study.SETTING: Midwestern urban oncology clinics and patient homes.SAMPLE: 25 Caucasian women, aged 40-65 years (-X = 54.3), with stage I or II breast cancer receiving doxorubicin-based chemotherapy.METHODS: The Piper Fatigue Scale, Hospital Anxiety and Depression Scale, Symptom Experience Scale, and Medical Outcomes Study Short-Form General Health Survey were completed before and after each treatment; 30, 60, and 90 days after the last treatment; and one year after the first treatment.MAIN RESEARCH VARIABLES: Fatigue, physical and psychological symptoms, and QOL.FINDINGS: Fatigue levels were moderately intense during treatments and decreased significantly over time. Sleep disturbances and pain were the most frequent, intense, and distressing other physical symptoms. Anxiety was highest at baseline, and depression was highest during the fourth chemotherapy treatment. Fatigue was correlated with other physical and psychological symptoms at some times during treatments and consistently following treatments. Higher fatigue was associated with lower QOL in several domains.CONCLUSIONS: Fatigue is associated with other physical and psychological symptoms that fluctuate during and after treatment. Higher fatigue compromises QOL.IMPLICATIONS FOR NURSING: Interventions targeting primary or cluster symptoms can reduce the impact of adjuvant chemotherapy on fatigue, other symptoms, and QOL.