Local exercise does not prevent the aortic stiffening response to acute prolonged sitting: a randomized crossover trial
Local exercise does not prevent the aortic stiffening response to acute prolonged sitting: a randomized crossover trial
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DOI：
10.1152/japplphysiol.00318.2019
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发表时间：
2019-09-01
影响因子：
3.3
通讯作者：
Hanson, Erik D.
中科院分区：
文献类型：
--
作者：
Evans, William S.;Stoner, Lee;Hanson, Erik D.
久坐已被证明会促进小腿内皮功能障碍。此外，据报道，简单的坐姿中断策略（包括提小腿）可以预防腿部内皮功能障碍。然而，目前尚不清楚长时间坐着是否会影响中枢心血管健康，或者简单的坐姿中断策略是否可以预防中枢心血管健康受损。这项研究试图回答两个问题：在年轻、健康的成年人中，1）长时间坐着（3小时）是否会导致主动脉僵硬增加，2）进行间歇性小腿抬高练习以防止淤积，从而防止主动脉僵硬。 20 名年轻健康参与者（21.7 +/- 2.5 岁，70% 女性，25.5 +/- 6.1 kg/m(2)）被随机分配坐 3 小时，每 10 分钟进行 10 次小腿抬高（CALF）或不进行（CON）。在坐前和坐后仰卧位测量主动脉硬化[颈动脉-股动脉脉搏波速度（PWV）]。使用近红外光谱仪根据总血红蛋白 (thB) 浓度来估计静坐期间的静脉汇集。没有条件 x 时间交互作用。静坐 3 小时后，PWV 显着增加（0.30 +/- 0.46 m/s，P < 0.001）。 PWV 没有条件效应（P = 0.694），表明间歇性小腿抬高并不能保护中枢心血管健康。坐姿对 tHb 没有显着影响 (P = 0.446)，但 CON 与 CALF 相比，tHb 高 1.9 μM (P = 0.106)。久坐会增加年轻健康个体的主动脉僵硬度，这一过程可能会受到下肢血液汇集的影响。据报道，小腿抬高可以保护腿部血管功能，但似乎并不能为维持中枢心血管健康提供足够的刺激。新的和值得注意的尽管坐立不安或抬高小腿等简单策略足以保护腿部血管功能，但当前研究的数据表明，此类策略不足以维持中枢心血管健康，而中枢心血管健康与心血管疾病有关。
Prolonged sitting has been shown to promote endothelial dysfunction in the lower legs. Furthermore, it has been reported that simple sitting-interruption strategies, including calf raises, prevent leg endothelial dysfunction. However, it is unclear whether prolonged sitting affects central cardiovascular health, or whether simple sitting-interruption strategies prevent impaired central cardiovascular health. This study sought to answer two questions: in young, healthy adults 1) does prolonged sitting (3 h) lead to increased aortic stiffness, and 2) do intermittent calf raise exercises to prevent pooling prevent aortic stiffening. Twenty young, healthy participants (21.7 +/- 2.5 yr, 70% female, 25.5 +/- 6.1 kg/m(2)) were randomized to 3 h of sitting with (CALF) or without (CON) 10 calf raises every 10 min. Aortic stiffening [carotid-femoral pulse wave velocity (PWV)] was measured in the supine position pre- and post-sitting. Venous pooling during sitting was estimated with total hemoglobin (tHB) concentration using near-infrared spectroscopy. There were no condition x time interactions. Following 3 h of sitting, PWV significantly increased (0.30 +/- 0.46 m/s, P < 0.001). There was no condition effect for PWV (P = 0.694), indicating the intermittent calf rises did not preserve central cardiovascular health. tHb was not significantly affected by sitting (P = 0.446) but was 1.9 mu M higher for CON versus CALF (P = 0.106). Sitting increases aortic stiffness in young, healthy individuals, a process that may be influenced by lower extremity blood pooling. Calf raises, which have been reported to preserve vascular function in the legs, do not appear to provide sufficient stimulus for maintaining central cardiovascular health.NEW & NOTEWORTHY Although simple strategies, such as fidgeting or calf raises, are sufficient for preserving vascular function in the legs, data from the current study indicate that such strategies are not sufficient for maintaining central cardiovascular health, which is linked to cardiovascular disease.