Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.

Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.
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DOI:
10.1016/j.coviro.2013.05.011
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发表时间:
2013-06
影响因子:
5.9
通讯作者:
Frueh, Klaus
Frueh, Klaus
中科院分区:
医学2区
文献类型:
--
作者:
Feng, Pinghui;Moses, Ashlee;Frueh, Klaus

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γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.
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