The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells.
The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells.
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E3s在调节胚胎干细胞和诱导多能干细胞的多能性中的作用
DOI：
10.3390/ijms22031168
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发表时间：
2021-01-25
影响因子：
5.6
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Wu Y;Zhang W
多能胚胎干细胞（ESC）来源于早期胚胎，可以分化为生物体中的任何类型的细胞。诱导多能干细胞（iPSCs）类似于ESC，两者都是研究早期胚胎发育和实现年龄相关退行性疾病和其他细胞功能障碍相关疾病的细胞替代疗法的绝佳来源。为了实现这些有价值的应用，全面了解多能性维持和获得的机制是至关重要的。泛素化在翻译后水平用泛素（Ub）修饰蛋白质以监测蛋白质的稳定性和活性。它广泛参与胚胎干细胞和诱导多能干细胞的多能特异性调节网络。泛素化通过Ub激活酶E1、Ub结合酶E2和Ub连接酶E3的顺序作用实现。与E1s和E2s相比，E3s是最丰富的，负责底物选择性和功能多样性。本文就E3连接酶在ESC调控中的作用进行综述。
Pluripotent embryonic stem cells (ESCs) are derived from early embryos and can differentiate into any type of cells in living organisms. Induced pluripotent stem cells (iPSCs) resemble ESCs, both of which serve as excellent sources to study early embryonic development and realize cell replacement therapies for age-related degenerative diseases and other cell dysfunction-related illnesses. To achieve these valuable applications, comprehensively understanding of the mechanisms underlying pluripotency maintenance and acquisition is critical. Ubiquitination modifies proteins with Ubiquitin (Ub) at the post-translational level to monitor protein stability and activity. It is extensively involved in pluripotency-specific regulatory networks in ESCs and iPSCs. Ubiquitination is achieved by sequential actions of the Ub-activating enzyme E1, Ub-conjugating enzyme E2, and Ub ligase E3. Compared with E1s and E2s, E3s are most abundant, responsible for substrate selectivity and functional diversity. In this review, we focus on E3 ligases to discuss recent progresses in understanding how they regulate pluripotency and somatic cell reprogramming through ubiquitinating core ESC regulators.
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影响因子：
23.9
作者：
Buckley, Shannon M.;Aranda-Orgilles, Beatriz;Strikoudis, Alexandros;Apostolou, Effie;Loizou, Evangelia;Moran-Crusio, Kelly;Farnsworth, Charles L.;Koller, Antonius A.;Dasgupta, Ramanuj;Silva, Jeffrey C.;Stadtfeld, Matthias;Hochedlinger, Konrad;Chen, Emily I.;Aifantis, Iannis
通讯作者：
Aifantis, Iannis
影响因子：
4.6
作者：
Cavallaro, Maurizio;Mariani, Jessica;Nicolis, Silvia K.
通讯作者：
Nicolis, Silvia K.
影响因子：
--
作者：
Chickarmane V;Olariu V;Peterson C
通讯作者：
Peterson C
影响因子：
64.8
作者：
Brons, I. Gabrielle M.;Smithers, Lucy E.;Vallier, Ludovic
通讯作者：
Vallier, Ludovic
DOI：
10.1073/pnas.1733908100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Arai, T;Kasper, JS;DeCaprio, JA
通讯作者：
DeCaprio, JA