THE ASSOCIATION BETWEEN CHOLESTEROL CHOLELITHIASIS AND CORONARY HEART-DISEASE IN FRAMINGHAM, MASSACHUSETTS
THE ASSOCIATION BETWEEN CHOLESTEROL CHOLELITHIASIS AND CORONARY HEART-DISEASE IN FRAMINGHAM, MASSACHUSETTS
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DOI：
10.1093/oxfordjournals.aje.a113978
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
MCNAMARA, PM
中科院分区：
文献类型：
--
作者：
BORTNICHAK, EA;FREEMAN, DH;MCNAMARA, PM
胆固醇结石病和动脉粥样硬化或其后遗症之间的关系一直被假定，但从未得到充分的证明。本研究的诊断胆固醇胆石症与随后发生的冠心病之间的关系的数据是从回顾自1952年以来作为Frachial Heart研究原始队列成员的5209名个体的预先存在的前瞻性收集的医疗记录中获得的。这些数据的初步单变量检查，没有纠正的条件或共享的风险因素的时间顺序，表明一个显着的适度的正相关性在男性中，但没有关系的女性。Logistic多元回归分析，考虑到时间顺序的影响和8个标准的冠心病危险因素，证实了这些发现。男性患者胆固醇结石的存在可能是不利的脂蛋白谱的指示。这些结果具有临床意义，因为男性胆结石患者发生后续冠状动脉疾病的风险增加，应进行相应的监测。这项研究标志着第一次使用纵向队列研究方法建立这些条件之间的关系。
A relationship between cholesterol gallstone disease and atherosclerosis or its sequellae has been postulated but has never been adequately proven. Data for this investigation of the relationship of diagnosed cholesterol cholelithiasis to subsequent incident coronary heart disease were obtained from a review of the pre-existing prospectively collected medical records of the 5209 individuals followed since 1952 as members of the original cohort of the Framingham Heart Study. Preliminary univariate examination of these data, making no correction for time ordering of the conditions or for shared risk factors, indicated a significant modest positive association in men but no relationship in women. Logistic multiple regression analyses, allowing for the effects of time ordering and for 8 standard coronary disease risk factors, confirmed these findings. The presence of cholesterol gallstones in male patients may have been indicative of an unfavorable lipoprotein profile. These results had clinical implications in that male gallstone patients were at increased risk for subsequent coronary disease and should be monitored accordingly. This investigation marked the 1st time that a relationship between these conditions was established using a longitudinal cohort study approach.