Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome
Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome
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DOI：
10.1016/j.eplepsyres.2009.03.013
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发表时间：
2009-08-01
影响因子：
2.2
通讯作者：
Tsuchiya, Shigeru
中科院分区：
文献类型：
--
作者：
Haginoya, Kazuhiro;Noguchi, Rie;Tsuchiya, Shigeru
我们测量了24例West综合征患者脑脊液（CSF）中促炎性和抗炎性细胞因子的水平，以阐明炎症细胞因子是否参与West综合征的病理生理。与对照组相比，西方综合征患者的三种促炎细胞因子，白细胞介素(IL)-1 β， IL-6和肿瘤坏死因子- α中的任何一种都没有显著升高。而西氏综合征患者脑脊液中抗炎细胞因子、IL-1受体拮抗剂水平明显降低。免疫系统紊乱是否参与了西氏综合征的病理生理机制尚需进一步研究。(C) 2009 Elsevier B.V.版权所有
We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome. (C) 2009 Elsevier B.V. All rights reserved.