A COMPARATIVE-STUDY OF THE BEHAVIORAL-EFFECTS OF D-AMPHETAMINE AND APOMORPHINE IN THE RAT
A COMPARATIVE-STUDY OF THE BEHAVIORAL-EFFECTS OF D-AMPHETAMINE AND APOMORPHINE IN THE RAT
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DOI：
10.1016/0091-3057(91)90398-l
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发表时间：
1991-05-01
影响因子：
3.6
通讯作者：
KAFETZOPOULOS, E
中科院分区：
文献类型：
--
作者：
ANTONIOU, K;KAFETZOPOULOS, E
为了更好地表征和比较多巴胺能激动剂诱导的行为效应，将各种剂量的d-苯丙胺和阿扑吗啡注射到大鼠中。这项研究是使用计算机技术进行量化和分析的各种行为元素。虽然两种药物都增加了运动活动，并提供了剂量依赖性的刻板反应，但在开放领域的整个行为模式显示出不同的结构。d-安非他明的剂量，不产生定型反应诱导了广泛的不同的行为元素，频率增加，但平均持续时间减少，而阿扑吗啡诱导了一个更有限的行为概况。此外，在低剂量的d-安非他明治疗后观察到更高频率的冷冻反应，但在阿扑吗啡治疗后没有观察到。两种药物在高剂量下都引起了类似的刻板症状，其特征是长时间的重复运动，但在低剂量下，行为模式完全不同。阿扑吗啡诱发的综合征以活动和嗅闻为主，以直立为中断;苯丙胺诱发的综合征以嗅闻和活动为主，以站立和冻结为中断。
A wide range of doses of d-amphetamine and apomorphine were injected into rats, in order to better characterize and compare dopaminergic agonist-induced behavioral effects. The study was carried out using a computerized technique for the quantification and analysis of various behavioral elements. Although both drugs increased motor activity and provided dose-dependent stereotyped responses, the whole pattern of behavior in the open field showed a different structure. d-Amphetamine in doses that did not produce stereotyped responses induced a wide range of varied behavioral elements with increased frequency but decreased mean duration, while apomorphine induced a more restricted behavioral profile. Furthermore, a higher frequency of freezing reaction was observed after d-amphetamine treatment in low doses but not after apomorphine treatment. Both drugs in high doses elicited a similar stereotyped syndrome characterized by repetitive movements of great duration, but at low doses the behavioral pattern was completely different. The apomorphine-induced syndrome was characterized mainly by moving and sniffing, interrupted by rearing, while the amphetamine-induced syndrome by sniffing and moving, interrupted by standing and freezing.