Transcription Regulation and Membrane Stress Management in Enterobacterial Pathogens.
Transcription Regulation and Membrane Stress Management in Enterobacterial Pathogens.
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DOI：
10.1007/978-3-319-32189-9_13
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发表时间：
2016-05
影响因子：
--
通讯作者：
Nan Zhang;G. Jovanovic;C. McDonald;O. Ces;Xiaodong Zhang;M. Buck
中科院分区：
文献类型：
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作者：
Nan Zhang;G. Jovanovic;C. McDonald;O. Ces;Xiaodong Zhang;M. Buck
时间和条件转录调控是肠道细菌病原体生命周期的基础。当接触到广泛的环境线索时，这些病原体通过RNA聚合酶和相关的西格玛因子来调节它们的基因表达。不同的西格玛因子，要么参与一般的“家务”，要么参与特定的反应，将RNA聚合酶引导到它们的同源启动子DNA。当被激活时，主要的替代因子sigma54帮助病原体管理压力并在其生态位中繁殖。在本章中，我们回顾了依赖于Sigma54的噬菌体休克蛋白(PSP)系统的功能和调控--当革兰氏阴性病原体遇到内膜损伤时，PSP系统是一个主要的应激反应。本文从不同的生物物理和生化途径出发，讨论了基因调控、信号转导和胁迫缓解机制的最新研究进展。
Transcription regulation in a temporal and conditional manner underpins the lifecycle of enterobacterial pathogens. Upon exposure to a wide array of environmental cues, these pathogens modulate their gene expression via the RNA polymerase and associated sigma factors. Different sigma factors, either involved in general ‘house-keeping’ or specific responses, guide the RNA polymerase to their cognate promoter DNAs. The major alternative sigma54 factor when activated helps pathogens manage stresses and proliferate in their ecological niches. In this chapter, we review the function and regulation of the sigma54-dependent Phage shock protein (Psp) system—a major stress response when Gram-negative pathogens encounter damages to their inner membranes. We discuss the recent development on mechanisms of gene regulation, signal transduction and stress mitigation in light of different biophysical and biochemical approaches.