Chagas cardiomyopathy and serologic testing in a small rural hospital in Chiapas, Mexico
Chagas cardiomyopathy and serologic testing in a small rural hospital in Chiapas, Mexico
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DOI：
10.1590/s1020-49892004000500009
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发表时间：
2004-05-01
期刊：
影响因子：
--
通讯作者：
Abad, Begoña
中科院分区：
文献类型：
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作者：
Capps, Linnea;Abad, Begoña
目标。在墨西哥恰帕斯州的一家小型农村医院进行一项研究，以：(1)检查诊断为充血性心力衰竭的患者中恰加斯心肌病的患病率；(2)评估医院献血者血清学阳性结果的患病率，试图确定恰加斯病是否仍然是心力衰竭的重要原因，至少在墨西哥的一些地区。本研究对2000-2002年间在该院就诊的充血性心力衰竭患者进行回顾性分析。从2002年4月开始，对献血者进行了为期6个月的血清学筛查。两组均采用间接血凝（IHA）或酶联免疫吸附试验（ELISA）或两种方法进行血清学检测。在67例心力衰竭患者中，没有其他导致心力衰竭的危险因素，其中40例进行了血清学检查。其中33例（82.5%）ELISA、IHA或两者均阳性。97名献血者中，一项或两项血清学检查阳性17人（17.5%）。这项研究进一步证明，恰加斯病在墨西哥一些地区仍然是导致心力衰竭的主要原因，如果捐献的血液没有得到持续的筛查，输血传播的风险仍然存在。
Objectives. To conduct a study in a small rural hospital located in the state of Chiapas, Mexico, to: (1) examine the prevalence of chagasic cardiomyopathy among patients with the diagnosis of congestive heart failure and (2) assess the prevalence of positive serologic results in blood donors in the hospital, in an attempt to ascertain whether Chagas' disease remains an important cause of heart failure at least in some areas of Mexico.Methods. The study of patients with cardiomyopathy was conducted by retrospective chart review of patients with the diagnosis of congestive heart failure treated at the hospital during the years 2000-2002. With the blood donors, the results of their serologic screening were reviewed for a six-month period beginning in April 2002. Serologic testing was done in both groups with either indirect hemagglutination (IHA) or enzyme-linked immunosorbent assay (ELISA), or with both.Results. Of 67 patients with heart failure and no risk factors for other causes of heart failure, 40 of them had serologic tests performed. Thirty-three of these 40 (82.5%) were positive by ELISA, IHA, or both. With 97 blood donors, one or both serologic tests were positive in 17 of them (17.5%).Conclusions. This research adds to the evidence that Chagas' disease continues to be a major cause of heart failure in some areas of Mexico and that there continues to be a risk of transmission by blood transfusion if donated blood is not consistently screened.