Remarkable similarity in genome nucleotide sequences between the Schwarz FF-8 and AIK-C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene.
Remarkable similarity in genome nucleotide sequences between the Schwarz FF-8 and AIK-C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene.
复制标题
Schwarz FF-8 和 AIK-C 麻疹病毒疫苗株之间的基因组核苷酸序列具有显着的相似性，并且磷蛋白基因中存在明显的核苷酸差异。
DOI：
10.1111/j.1348-0421.2011.00339.x
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发表时间：
2011
影响因子：
2.6
通讯作者：
Ogura H.
中科院分区：
文献类型：
--
作者：
Ito C;Ohgimoto S;Kato S;Sharma LB;Ayata M;Komase K;Takeuchi K;Ihara T;Ogura H.
施瓦茨FF-8（FF-8）和AIK-C麻疹病毒疫苗株目前在日本用于接种。在此，FF-8菌株的完整基因组核苷酸序列已经确定，并且发现其基因组序列与AIK-C菌株的基因组序列非常相似。这两种菌株仅通过磷蛋白基因中的两个核苷酸差异来区分。由于FF-8菌株在磷酸化和融合蛋白中不具有分别导致AIK-C菌株的温度敏感性和小合胞体形成表型的氨基酸取代，因此其他未鉴定的共同机制可能使FF-8和AIK-C菌株均减毒。
The Schwarz FF‐8 (FF‐8) and AIK‐C measles virus vaccine strains are currently used for vaccination in Japan. Here, the complete genome nucleotide sequence of the FF‐8 strain has been determined and its genome sequence found to be remarkably similar to that of the AIK‐C strain. These two strains are differentiated only by two nucleotide differences in the phosphoprotein gene. Since the FF‐8 strain does not possess the amino acid substitutions in the phospho‐ and fusion proteins which are responsible for the temperature‐sensitivity and small syncytium formation phenotypes of the AIK‐C strain, respectively, other unidentified common mechanisms likely attenuate both the FF‐8 and AIK‐C strains.