Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs.
Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs.
复制标题
促肾上腺皮质激素释放因子刺激大鼠垂体促肾上腺皮质激素中 3, 5-单磷酸腺苷的积累。
DOI：
10.1126/science.6281886
复制
发表时间：
1982
期刊：
影响因子：
56.9
通讯作者：
A. Schally
中科院分区：
文献类型：
--
作者：
F. Labrie;R. Veilleux;G. Lefèvre;D. Coy;J. Sueiras;A. Schally
合成绵羊促肾上腺皮质激素释放因子的存在导致原代培养的大鼠垂体促肾上腺皮质激素富集群体中腺苷 3', 5'-单磷酸积累的快速而显着的刺激。早在添加促肾上腺皮质激素释放因子后60秒就观察到这种增加，表明细胞内环核苷酸浓度的变化与促肾上腺皮质激素响应促肾上腺皮质激素释放因子的分泌同时或先于其分泌。
The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3', 5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.