Diagnosis of type I cryoglobulinaemia made through identifying crystals in the blood smear
Diagnosis of type I cryoglobulinaemia made through identifying crystals in the blood smear
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通过识别血涂片中的晶体诊断 I 型冷球蛋白血症
DOI：
10.1111/j.1440-0960.2009.00559.x
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发表时间：
2009
影响因子：
2
通讯作者：
S. Shireen
中科院分区：
文献类型：
--
作者：
Kyoko Shirato;C. Reid;J. Ibbetson;P. Hissaria;S. Shireen
我们报告一例I型冷球蛋白血症，患者为52岁男性，表现为广泛的皮肤坏死。诊断不能早期确定，因为反复测试低温球蛋白是阴性的，尽管仔细收集方法。1年后，在偶然的全血涂片上发现晶体，这是诊断这种疾病的一种不常见的方法。我们讨论的困难，我们所面临的建立诊断和强调需要重复的低温球蛋白测试在这种临床设置。在这种情况下，应考虑进行血液涂片检查。
We report a case of type I cryoglobulinaemia in a 52‐year‐old man who presented with widespread cutaneous necrosis. The diagnosis could not be established early on, as repeated testing for cryoglobulin was negative despite a careful collection method. The diagnosis was made 1 year later, on an incidental full blood smear that revealed crystals, which is an uncommon way to diagnose this condition. We discuss the difficulties we faced in establishing the diagnosis and emphasise the need for repeat cryoglobulin testing in this clinical setting. In such cases, examination of a blood smear should be considered.