Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children.
Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children.
复制标题
DOI：
10.1016/j.biopsych.2011.03.015
复制
发表时间：
2011-08-01
影响因子：
10.6
通讯作者：
Brain Development Cooperative Group
中科院分区：
文献类型：
--
作者：
Ducharme S;Hudziak JJ;Botteron KN;Ganjavi H;Lepage C;Collins DL;Albaugh MD;Evans AC;Karama S;Brain Development Cooperative Group
前扣带皮层（ACC）、眶额皮层（OFC）和基底神经节与病理性攻击有关。本研究旨在确定健康儿童冲动性攻击的神经解剖学相关性。193名6-18岁健康儿童的数据来自NIH正常脑发育MRI研究，经过盲法质量控制。皮质厚度和皮质下体积用自动软件获得。攻击水平采用儿童行为量表（CBCL）中的攻击行为量表（AGG）进行测量。AGG评分对皮质厚度和基底神经节体积使用一阶和二阶线性模型进行回归，同时控制年龄，性别，扫描部位和总脑体积。分析了“性别与AGG”的相互作用。双侧纹状体体积与AGG评分呈正相关（右侧：r=0.238，p=0.001;左侧：r=0.188，p=0.01）。在二阶线性模型中，发现右侧ACC和膝下ACC皮质厚度显著相关（p<0.05，校正）。高AGG评分与右侧ACC皮质相对较薄相关。在双侧眶额肌和前扣带肌与AGG评分的关系中发现了“AGG与性别”的相互作用趋势。这项研究表明，健康儿童的冲动性攻击与纹状体和右前扣带回的结构之间存在着联系，同时也表明，在OFC/ACC灰质中存在着性别特异性的关联模式。这些结果可能会指导对对立反抗和行为障碍的研究。
The anterior cingulate cortex (ACC), orbito-frontal cortex (OFC) and basal ganglia have been implicated in pathological aggression. This study aimed at identifying neuroanatomical correlates of impulsive aggression in healthy children. Data from 193 representative 6–18 year-old healthy children were obtained from the NIH MRI Study of Normal Brain Development after a blinded quality control. Cortical thickness and subcortical volumes were obtained with automated software. Aggression levels were measured with the Aggressive Behavior scale (AGG) of the Child Behavior Checklist (CBCL). AGG scores were regressed against cortical thickness and basal ganglia volumes using first and second-order linear models while controlling for age, gender, scanner site and total brain volume. ‘Gender by AGG’ interactions were analyzed. There were positive associations between bilateral striatal volumes and AGG scores (right: r=0.238, p=0.001; left: r=0.188, p=0.01). A significant association was found with right ACC and subgenual ACC cortical thickness in a second-order linear model (p<0.05, corrected). High AGG scores were associated with a relatively thin right ACC cortex. An ‘AGG by gender’ interaction trend was found in bilateral OFC and ACC associations with AGG scores. This study shows the existence of relationships between impulsive aggression in healthy children and the structure of the striatum and right ACC. It also suggests the existence of gender specific patterns of association in OFC/ACC grey matter. These results may guide research on oppositional-defiant and conduct disorders.