The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis -: A hypothesis
The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis -: A hypothesis
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DOI：
10.1016/j.mehy.2005.03.025
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发表时间：
2005-01-01
影响因子：
4.7
通讯作者：
Smit, TH
中科院分区：
文献类型：
--
作者：
Castelein, RM;van Dieën, JH;Smit, TH
青少年特发性脊柱侧凸（AIS）是一种男性独有的疾病，其发病机制一直是许多研究的主题，但仍知之甚少。先前的工作表明，矢状面中椎骨的向后倾斜在AIS的进展中具有预后意义，并且人类脊柱的某些区域可能会受到背侧剪切力的影响，这取决于姿势，这与其他脊椎动物中发现的不同。我们假设，这些背侧剪切力，专门作用于人体脊柱的特定区域，可能有助于脊柱的旋转不稳定。根据Hueter-Votkmann的说法，椎骨后部的不对称负荷将导致椎骨特定部分的所有三个平面的不对称生长。神经中枢的不对称生长。例如，脊椎的软骨已经被证明会导致生长猪的AIS样畸形，并且可以解释人类畸形的发展和进展。(c)2005爱思唯尔有限公司保留所有权利。
The pathogenesis of adolescent idiopathic scoliosis (AIS), a condition exclusive to man, has been the subject of many studies, but remains little understood. Previous work has shown that backward inclination of vertebrae in the sagittal plane has prognostic significance in the progression of AIS, and that certain regions of the human spine may be subject to dorsal shear forces, depending on posture, unlike what is found in other vertebrates. We postulate that these dorsal shear forces, acting exclusively upon specific regions of the human spine, may contribute to rotational instability of the spine. Asymmetric loading of the posterior parts of the vertebrae then would lead to asymmetrical growth in all three planes of specific parts of vertebrae, according to Hueter-Votkmann's taw. Asymmetrical growth of the neurocentral. cartilage of the vertebra, for instance, has been shown to lead to AIS-Like deformities in growing pigs, and could explain the development and progression of the deformity in humans. (c) 2005 Elsevier Ltd. All rights reserved.