Impact of lymphovascular invasion in patients with stage I gastric cancer
Impact of lymphovascular invasion in patients with stage I gastric cancer
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DOI：
10.1016/j.surg.2009.08.012
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发表时间：
2010-02-01
期刊：
影响因子：
3.8
通讯作者：
Takahashi, Masazumiu
中科院分区：
文献类型：
--
作者：
Kunisaki, Chikara;Makino, Hirochika;Takahashi, Masazumiu
背景I期胃癌患者尽管手术效果良好，但仍经常发生肿瘤复发。因此，重要的是要确定预后因素，以改善这种结果。从1985年4月到2000年3月，共有1880例经组织学证实的I期胃癌患者被纳入本研究。对这些患者的手术结果（生存时间、预后因素、复发模式）进行评估。对所有I期胃癌患者的多因素分析显示，浸润深度、淋巴结转移和淋巴管浸润独立影响预后。此外，通过多变量分析，高龄动物园被选为IA期患者的独立预后因素，而淋巴血管浸润被选为IB期胃癌患者的独立预后因素。TIN 1期伴中、重度淋巴管浸润、T2 N 0期伴中、重度淋巴管浸润和II期患者的5年生存率分别为95.1%、83.5%和76.9%。T1 N1期和11期之间的生存时间有显著差异（P= 0.0189），但T1 N1期和T2 N 0期或T2 N 0期和II期之间无显著差异。T2 N 0胃癌伴中、重度淋巴管浸润者可能适合行辅助化疗。（Surgery 2010; 14 7：204-11）
Background. Patients with stage I gastric cancer often suffer from tumor recurrence despite a generally favorable operative outcome. It is therefore important to determine the prognostic factors in order to improve such outcomes.Methods. Between April 1985 and March 2000, a total of 1, 880 patients with histologically proven stage I gastric cancer were included in this study. Operative outcomes (survival time, prognostic factors, Pattern of recurrence) were evaluated in these patients.Results. Multivariate analysis in patients with all stage I gastric cancer revealed that depth of invasion, lymph node metastasis, and lymphovascular invasion independently influenced prognosis. Moreover, advanced age zoos selected as an independent prognostic factor in patients with stage IA, and lymphovascular invasion in patients with stage IB gastric cancer by multivariate analyses. The 5-year survival rates in stage TIN1 patients with moderate to severe lymphovascular invasion, T2N0 with moderate to severe lymphovascular invasion, and II were 95.1%, 83.5%, and 76 9%, respectively. There was a significant difference in survival time between stage T1N1 and 11 (P=.0189) but not between stage T1N1 and T2N0 or stage T2N0 and II.Conclusion. T2N0 gastric cancer patients with moderate to severe lymphovascular invasion may be suitable candidates for adjuvant chemotherapy. (Surgery 2010; 14 7:204-11)