Mapping of chemical trigger zones for reward
Mapping of chemical trigger zones for reward
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DOI：
10.1016/j.neuropharm.2004.07.012
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发表时间：
2004-01-01
影响因子：
4.7
通讯作者：
Wise, RA
中科院分区：
文献类型：
--
作者：
Ikemoto, S;Wise, RA
令人上瘾的药物被认为激活了大脑电路，而大脑电路通常会调节更自然的奖励，如食物或水。药物激活大脑内突触连接处的这一电路；识别发生这种情况的连接为了解该电路的神经化学和解剖学特征提供了线索。识别药物与这一回路相互作用的连接点的一种方法是确定动物是否会杠杆按压，要求局部注射成瘾药物。这种方法已经确定了GABA能、多巴胺能、谷氨酸能和胆碱能触发区位于对自然奖赏功能重要的中脑皮质边缘回路。爱思唯尔有限公司出版。
Addictive drugs are thought to activate brain circuitry that normally mediates more natural rewards such as food or water. Drugs activate this circuitry at synaptic junctions within the brain; identifying the junctions at which this occurs provides clues to the neurochemical and anatomical characteristics of the circuitry. One approach to identifying the junctions at which drugs interact with this circuitry is to determine if animals will lever-press for site-specific microinjections of addictive drugs. This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function. Published by Elsevier Ltd.