Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS
Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS
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DOI：
10.1016/s0197-4580(00)00106-8
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发表时间：
2000-01-01
影响因子：
4.2
通讯作者：
Launer, LJ
中科院分区：
文献类型：
--
作者：
Petrovitch, H;White, LR;Launer, LJ
中年高血压与认知障碍、血管性痴呆（VSD）以及可能的阿尔茨海默病（AD）的后期发展有关。神经病理性脑血管病变和脑萎缩与血压升高有关，然而，据我们所知，尚未有对中年测量的血压水平与阿尔茨海默病微观病变之间关联的前瞻性研究。我们研究了檀香山心脏项目/檀香山 - 亚洲老龄化研究（HHP/HAAS）队列中的日裔美国男性中年血压水平与神经原纤维缠结（NFT）、神经炎斑块（NP）以及尸检时脑重量减轻之间的关系。HHP/HAAS是一项基于人群的认知功能和痴呆纵向研究，随访了36年。对243名死者的新皮质和海马体每平方毫米的NFT和NP进行计数，并测量固定脑重量。中年收缩压升高（≥160 mmHg）与脑重量减轻以及新皮质和海马体中NP数量增多有关。舒张压升高（≥95 mmHg）与海马体中NFT数量增多有关。结果表明，除了已知的高血压与神经病理性脑血管病变的关联外，它还与脑萎缩、NP和NFT有直接关系。（C）2000爱思唯尔科学公司。保留所有权利。
Midlife hypertension is associated with later development of cognitive impairment, vascular dementia (VsD), and possibly Alzheimer's disease (AD). Neuropathic cerebrovascular lesions and brain atrophy have been associated with elevated blood pressure (BP), however, to our knowledge there have been no prospective investigations of an association of blood pressure levels measured in midlife with the microscopic lesions of AD. The investigated the relationship of BP level in midlife to development of neurofibrillary tangles (NFT), neuritic plaques (WP), and low brain weight at autopsy among Japanese-American men who were members of the Honolulu Heart Program/Honolulu-Asia aging Study (HHP/HAAS) cohort. The HHP/HAAS is a population-based, longitudinal study of cognitive function and dementia with 36 years of follow-up. Neocortical and hippocampal NFT and NP were counted per mm(2) and fixed brain weight was measured for 243 decedents. Elevated systolic BP, (greater than or equal to 160 mm Hg) in midlife was associated with low brain weight and greater numbers of NP in both neocortex and hippocampus. Diastolic BP elevation, (greater than or equal to 95 mm Hg) was associated with greater numbers of NFT in hippocampus. Results indicate that in addition to the accepted association of high BP with neuropathic cerebrovascular lesions, there is a direct relationship with brain atrophy, NP and NFT. (C) 2000 Elsevier Science Inc. All rights reserved.