Sleep and sensorimotor integration during early vocal learning in a songbird
Sleep and sensorimotor integration during early vocal learning in a songbird
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DOI：
10.1038/nature07615
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发表时间：
2009-03-05
期刊：
影响因子：
64.8
通讯作者：
Margoliash, Daniel
中科院分区：
文献类型：
--
作者：
Shank, Sylvan S.;Margoliash, Daniel
行为学研究广泛地将睡眠与一系列行为学习中的记忆巩固联系起来（1-4）。在睡眠期间，大脑区域被重新激活（5,6），特定的神经活动模式被重播（7-10），与之前清醒行为中观察到的模式一致。鸟鸣学习是一种技能学习的范式系统（11-14）。幼斑胸草雀（Taeniopygia guttata）鸣叫发育的特点是歌唱行为的睡眠依赖性昼夜波动，睡眠后鸣叫结构立即恶化，随后在当天晚些时候恢复（15）。在睡眠中的成年鸟类中，强健的翅果核（RA）中前脑前运动神经元的自发爆发活动携带着白天鸣叫的信息（16）。在这里，我们表明，在幼年斑胸草雀中，白天播放成年“导师”之歌会在接下来的睡眠中引起RA神经元爆发活动的深刻且特定于导师之歌的变化。夜间神经元的变化先于教师歌曲引起的歌唱变化，这是第二天首次观察到的。听觉反馈的中断大大减少了睡眠爆发，并阻止了教师歌曲特异性神经元的重构。因此，夜间神经元活动是由歌曲模型（感觉模板）和听觉反馈的相互作用形成的，在与声乐学习相关的练习开始之前，夜间活动发生了变化。我们假设夜间爆发在睡眠中诱发运动前网络的适应性变化，作为声音学习的一部分。根据这一假设，由夜间感觉信息的回放和白天感觉反馈的评估驱动的适应性变化相互作用，产生了复杂的昼夜节律模式，在早期的声音发育中可以看到。
Behavioural studies widely implicate sleep in memory consolidation in the learning of a broad range of behaviours(1-4). During sleep, brain regions are reactivated(5,6), and specific patterns of neural activity are replayed(7-10), consistent with patterns observed in previous waking behaviour. Birdsong learning is a paradigmatic model system for skill learning(11-14). Song development in juvenile zebra finches (Taeniopygia guttata) is characterized by sleep-dependent circadian fluctuations in singing behaviour, with immediate post-sleep deterioration in song structure followed by recovery later in the day(15). In sleeping adult birds, spontaneous bursting activity of forebrain premotor neurons in the robust nucleus of the arcopallium (RA) carries information about daytime singing(16). Here we show that, in juvenile zebra finches, playback during the day of an adult 'tutor' song induced profound and tutor-song-specific changes in bursting activity of RA neurons during the following night of sleep. The night-time neuronal changes preceded tutor-song-induced changes in singing, first observed the following day. Interruption of auditory feedback greatly reduced sleep bursting and prevented the tutor-song-specific neuronal remodelling. Thus, night-time neuronal activity is shaped by the interaction of the song model (sensory template) and auditory feedback, with changes in night-time activity preceding the onset of practice associated with vocal learning. We hypothesize that night-time bursting induces adaptive changes in premotor networks during sleep as part of vocal learning. By this hypothesis, adaptive changes driven by replay of sensory information at night and by evaluation of sensory feedback during the day interact to produce the complex circadian patterns seen early in vocal development.