Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome.
Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome.
复制标题
内皮素 B 受体对多囊卵巢综合征女性外周微血管功能的贡献。
DOI：
10.1113/jphysiol.2011.216218
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Stachenfeld,NinaS
中科院分区：
文献类型：
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作者：
Wenner,MeganM;Taylor,HughS;Stachenfeld,NinaS
虽然多囊卵巢综合征（PCOS）的核心特征是激素失衡，但这种综合征与肥胖、胰岛素抵抗、高血压和内皮功能障碍有关。这一系列因素导致不孕症、糖尿病和心血管疾病的风险增加。在这项研究中，我们研究了两个重要的受体参与内皮功能，ET-A和ET-B，使用皮肤微循环检查小血管反应。我们证明ET B受体可能在PCOS女性心血管疾病的病理生理学中发挥重要作用。
Non‐Technical SummaryAlthough the core feature in polycystic ovary syndrome (PCOS) is a hormonal imbalance, this syndrome is associated with obesity, insulin resistance, hypertension and endothelial dysfunction. This constellation of factors leads to greater risks for infertility, diabetes and cardiovascular disease. In this study we examine two important receptors involved in endothelial function, ET‐A and ET‐B, using the skin microcirculation to examine small blood vessel responses. We demonstrate that the ET‐B receptor is likely to play an important role in the pathophysiology of cardiovascular disease in women with PCOS.