Embolic mycotic encephalitis in a cow following Mortierella wolfii infection of a surgery site
Embolic mycotic encephalitis in a cow following Mortierella wolfii infection of a surgery site
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手术部位沃尔氏被孢霉感染后奶牛发生栓塞性真菌性脑炎
DOI：
10.1177/1040638717710684
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发表时间：
2017
影响因子：
1.5
通讯作者：
M. Kiupel
中科院分区：
文献类型：
--
作者：
Benjamin Curtis;C. Hollinger;A. Lim;M. Kiupel
一头5岁的荷斯坦奶牛在产后10 d因疑似皱胃移位而接受手术，19 d出现急性神经系统症状，产后21 d发现死亡。尸检时，切口周围肌内脓肿与腹膜腔相通，出血和软化累及大脑，肝脏、肾脏和肺部有多个结节。在组织学上，在手术部位、肝脏表面以及肺、肾、脑和肝脏的严重坏死性血管炎病变中观察到真菌菌丝。子宫内无真菌。经全菌PCR和DNA测序鉴定，该菌为沃尔菲被孢霉（Mortierella wolfii）。此前报道的死亡病例为M。沃尔夫氏菌与流产有关，但在本例中，子宫内没有真菌生物体的组织学证据，产犊是常规的，产犊和神经系统体征的出现之间有几周的延迟。结果表明，一个独特的情况下，手术部位感染，随后栓塞真菌病。
A 5-y-old Holstein dairy cow had surgery for a suspected displaced abomasum 10 d postpartum, developed acute neurologic signs at day 19, and was found dead 21 d postpartum. At autopsy, there was a peri-incisional intramuscular abscess that communicated with the peritoneal cavity, as well as hemorrhage and malacia involving the brain, and multiple nodules in the liver, kidneys, and lungs. Fungal hyphae were seen histologically at the surgery site, on the surface of the liver, and in lesions of severe necrotizing vasculitis in the lungs, kidneys, brain, and liver. The uterus was free of fungal organisms. Pan-fungal PCR and DNA sequencing identified the fungus as Mortierella wolfii. Previously reported deaths from M. wolfii have been related to abortion, but in this case, there was no histologic evidence of fungal organisms in the uterus, calving was routine, and there was a several week delay between calving and development of neurologic signs. The findings suggested a unique case of surgical site infection with subsequent embolic mycosis.