Polymorphic human somatostatin gene is located on chromosome 3.
Polymorphic human somatostatin gene is located on chromosome 3.
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多态性人类生长抑素基因位于3号染色体上。
DOI：
10.1073/pnas.80.9.2686
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发表时间：
1983
影响因子：
11.1
通讯作者：
Shows,TB
中科院分区：
文献类型：
--
作者：
Naylor,SL;Sakaguchi,AY;Shen,LP;Bell,GI;Rutter,WJ;Shows,TB
生长抑素是一种由14个氨基酸组成的神经肽和激素，可抑制多种肽激素的分泌。人类生长抑素基因SST已克隆成功，序列已确定。该克隆被用作染色体定位研究的探针，以检测人鼠杂交体中的人生长抑素序列。对41个杂交种（包括一些包含人类染色体易位的杂交种）进行Southern blot分析，发现SST位于3号染色体q21引物的四分之一区。利用生长抑素基因探针对来自无亲缘关系个体的人类dna进行限制性内切片段多态性筛选。发现了两个多态性：(i)位于基因3'端的EcoRI变异，在白种人、美国黑人和亚洲人群中发现，频率约为0.10;（ii）内含子中的BamHI变异，在白种人中出现，频率为0.13。
Somatostatin is a 14-amino-acid neuropeptide and hormone that inhibits the secretion of several peptide hormones. The human gene for somatostatin SST has been cloned, and the sequence has been determined. This clone was used as a probe in chromosome mapping studies to detect the human somatostatin sequence in human-rodent hybrids. Southern blot analysis of 41 hybrids, including some containing translocations of human chromosomes, placed SST in the q21 leads to qter region of chromosome 3. Human DNAs from unrelated individuals were screened for restriction fragment polymorphisms detectable by the somatostatin gene probe. Two polymorphisms were found: (i) an EcoRI variant located at the 3' end of the gene, found in Caucasian, U.S. Black, and Asian populations with a frequency of approximately 0.10 and (ii) a BamHI variant in the intron, which occurs in Caucasians at a frequency of 0.13.