Variations in the Size of the Major Omentum Are Primarily Determined by Fat Cell Number
Variations in the Size of the Major Omentum Are Primarily Determined by Fat Cell Number
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DOI：
10.1210/jc.2012-4106
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发表时间：
2013-05-01
影响因子：
5.8
通讯作者：
Ryden, Mikael
中科院分区：
文献类型：
--
作者：
Arner, Peter;Andersson, Daniel Peter;Ryden, Mikael
目的：内脏脂肪组织（VAT）的积累与胰岛素抵抗密切相关。任何脂肪贮库的大小的变化由脂肪细胞体积和/或数量的改变决定。后者的每个因素的个人贡献，在大网膜，一个完全可切除的增值税depot.Subjects：总切除大网膜（网膜切除术）进行减肥手术结合在55名肥胖患者。测定网膜中的组织重量以及平均脂肪细胞大小和数量。在亚组中，通过计算机断层扫描（n = 17）或双能X线吸收测定法（n = 34）估计总VAT。结果：大网膜重量（平均0.6 kg）与通过计算机断层扫描或双能X线吸收测定法估计的总VAT质量显著相关（r = 0.48-0.7; P <0.01）。大网膜重量与全身脂肪的关系与代谢综合征的几个特征相关，与血清瘦素呈负相关（P <0.001）。平均脂肪细胞大小和总脂肪细胞数与网膜重量密切相关（r = 0.6-0.8; P <0.0001），与体重指数和全身脂肪质量无关，并且几乎完全解释了网膜大小的个体间差异。然而，逐步回归分析表明，脂肪细胞的数量是显着（P <0.0001）更重要的（62%）比脂肪细胞的大小（35%h.Conclusion：大网膜的大小是VAT质量的代表，并与有害的代谢档案。网膜重量的变化主要由脂肪细胞数量决定，在较小程度上由脂肪细胞大小决定，这表明肥胖症中VAT质量的增加主要依赖于脂肪细胞增殖。
Objective: Accumulation of visceral adipose tissue (VAT) is strongly linked to insulin resistance. Variations in the size of any adipose depot are determined by alterations in adipocyte volume and/or number. The individual contribution of each of the latter factors was determined in the major omentum, a fully resectable VAT depot.Subjects: Total removal of the major omentum (omentectomy) was performed in conjunction with bariatric surgery in 55 obese patients. Tissue weight as well as mean adipocyte size and number in the omentum were determined. In subgroups, total VAT was estimated by computerized tomography (n = 17) or dual-energy x-ray absorptiometry (n = 34).Results: The weight of the major omentum (on average 0.6 kg) correlated significantly with total VAT mass estimated by computerized tomography or dual-energy x-ray absorptiometry (r = 0.48-0.7; P < .01). Omental weight in relation to total body fat correlated with several features of the metabolic syndrome and inversely with serum-leptin (P < .001). Mean adipocyte size and total adipocyte number correlated strongly with omental weight (r = 0.6-0.8; P < .0001), irrespective of body mass index and total body fat mass, and accounted almost in total for interindividual variations in omental size. However, stepwise regression analysis demonstrated that adipocyte number was significantly (P < .0001) more important (62%) than adipocyte size (35%).Conclusion: The size of the major omentum is representative for VAT mass and correlates with a pernicious metabolic profile. Variations in omental weight are primarily determined by adipocyte number and to a lesser degree by adipocyte size, suggesting that increased VAT mass in obesity is predominantly dependent on adipocyte proliferation.