Effectiveness of bone cement containing tobramycin. An in vitro susceptibility study of 99 organisms found in infected joint arthroplasty.
Effectiveness of bone cement containing tobramycin. An in vitro susceptibility study of 99 organisms found in infected joint arthroplasty.
复制标题
含有妥布霉素的骨水泥的有效性。
DOI：
--
复制
发表时间：
1999
影响因子：
--
通讯作者：
J. Dumbleton
中科院分区：
文献类型：
--
作者：
C. Scott;Paul Higham;J. Dumbleton
我们使用了99株代表骨科感染的微生物，采用改良的体外Kirby-Bauer敏感性模型来检查含妥布霉素的骨水泥的有效性。菌谱广泛，包括革兰氏阳性和革兰氏阴性需氧菌、厌氧菌和分枝杆菌。添加妥布霉素的Simplex P对大多数菌株有效，包括对典型全身水平的妥布霉素具有抗性的菌株。尽管体外和体内结果之间难以直接相关，但研究表明妥布霉素对骨水泥的放热聚合稳定，并且妥布霉素从骨水泥表面释放的浓度足以抑制关节成形术后可能遇到的大多数微生物的生长。
We used 99 strains of organisms representative of orthopaedic infections to examine the effectiveness of a bone cement containing tobramycin, employing a modified in vitro Kirby-Bauer susceptibility model. The spectrum was broad, including Gram-positive and Gram-negative aerobic organisms, anaerobes and mycobacteria. Simplex P with added tobramycin was effective against most of the strains, including those which are resistant to typical systemic levels of tobramycin. Although direct correlation between in vitro and in vivo results is difficult, the study showed that tobramycin is stable to the exothermic polymerisation of the cement, and that it is released from the surface of the cement at concentrations high enough to inhibit the growth of most organisms which may be encountered after joint arthroplasty.
影响因子：
5.9
作者：
INMAN, RD;GALLEGOS, KV;CHRISTIAN, CL
通讯作者：
CHRISTIAN, CL