Er3+ -doped ZnAl-LDH withnear-infrared emissions used forthedelivery andrelease of5-fluorouracil invitro
Er3+ -doped ZnAl-LDH withnear-infrared emissions used forthedelivery andrelease of5-fluorouracil invitro
复制标题
具有近红外发射功能的 Er3 掺杂 ZnAl-LDH 用于体外递送和释放 5-氟尿嘧啶
DOI：
10.1007/s13738-022-02513-y
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yongxiu Li
中科院分区：
文献类型：
--
作者：
Siyu Yin;Yufeng Chen;Chao Li;Xingxing Qiu;Yajiao Zhang;Yongxiu Li
研究了具有近红外发射的掺铒锌铝层状双氢氧化物（Er 3 +-doped ZnAl-LDH）作为抗癌药物5-氟尿嘧啶（5-Fu）的载体和释放。组成和结构分析表明，5-Fu成功地插入了掺Er ~（3+）的ZnAl-LDH的层间，插入后的LDH的层间距在8.78 ~ 14.32 nm之间变化。5-Fu在模拟肠介质（pH7.4的磷酸盐缓冲液，37 ℃）中控制释放。5-Fu的释药行为表现为先快后慢的释药过程。此外，5-Fu嵌入到掺Er ~（3+）的ZnAl-LDH中，大大降低了掺Er ~（3+）的ZnAl-LDH的近红外发射，而释放5-Fu后，近红外发射又恢复了。近红外发射的变化可能是一种有用的技术，用于标记特定部位的5-Fu的交付和释放。因此，掺Er 3+的ZnAl-LDH具有廉价、无毒、生物相容性好、对生物组织损伤小等优点，有望成为一种具有标记或标记功能的药物载体。
Erbium-doped zinc-aluminum layered double hydroxide (Er3+-doped ZnAl-LDH) with near-infrared emission has been studied as the delivery and release of the 5-fluorouracil (5-Fu) which was an anticancer drug. Compositional and structural analyses reveal that the 5-Fu has been successfully intercalated into the interlayer of Er3+-doped ZnAl-LDH, and the basal spacing of the Er3+-doped LDH varied from 8.78 to 14.32 Å after the intercalation of 5-Fu. The release of 5-Fu was controlled in simulated intestinal medium (phosphate buffer solutions with pH 7.4 and 37 ℃). The releasing behavior of 5-Fu showed an initial quick-release followed by a slow-release. What is more, the intercalation of 5-Fu into the Er3+-doped ZnAl-LDH greatly reduced the near-infrared emissions of the Er3+-doped ZnAl-LDH, whereas the near-infrared emissions were recovered after the release of 5-Fu. The change of near-infrared emissions may be a useful technique for marking the delivery and release of 5-Fu at specific sites. Therefore, the Er3+-doped ZnAl-LDH with cheapness, non-toxicity, bio-compatibility, and little damage to biological tissue, may be a promising drug delivery system with marking or labeling function.