Histologic evaluation of human alveolar sockets treated with an artificial bone substitute material.
Histologic evaluation of human alveolar sockets treated with an artificial bone substitute material.
复制标题
用人造骨替代材料处理的人牙槽窝的组织学评估。
DOI：
10.1097/scs.0b013e318208bacf
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Moy,PeterK
中科院分区：
文献类型：
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作者：
Wakimoto,Mari;Ueno,Takaaki;Hirata,Azumi;Iida,Seiji;Aghaloo,Tara;Moy,PeterK
这项研究涉及组织学、酶组织学、免疫组织学和三维显微结构，评估人工骨替代物在人牙槽窝内成骨和修复的程度。7例患者拔牙后，拔牙窝腔内填充MasterMigrate(15%羟基磷灰石，85%β-磷酸三钙复合体)。对种植体植入过程中采集的标本进行放射显微镜检查和组织学检查。在显微计算机断层扫描上，所有收集的样本中都观察到了新骨，并观察到人工骨替代物周围发生了成骨。组织学上，观察到的整个区域都有活跃的成骨现象。在主移植物周围可观察到新的骨组织，并存在成骨细胞样细胞。部分侵入人工骨的细胞包括抗酒石酸酸性磷酸酶阳性细胞和CD34阳性细胞。这些结果表明，Master植骨人工骨在颌骨中诱导成骨，似乎是修复骨缺损的有效材料。
This study involved a histologic, enzyme histologic, immunohistologic, and three-dimensional microstructure evaluating the extent of osteogenesis and repair in the human alveolar extraction socket achievable with an artificial bone substitute. After tooth extraction in 7 patients, extraction sockets were filled with Mastergraft (15% hydroxyapatite, 85% β-tricalcium phosphate complex). Radiomicrographs and histologic examinations were performed on samples obtained during dental implant placement procedure. On micro-computed tomography, new bone was observed in all collected samples, and osteogenesis was observed to have taken place around the artificial bone substitute. Histologically, active osteogenesis was found throughout the region observed. Addition of new bone around the Mastergraft was observed, and osteoblast-like cells were present. Cells that had partially invaded the artificial bone included tartrate-resistant acid phosphate-positive and CD34-positive cells. These findings indicate that the Mastergraft artificial bone induced osteogenesis in the jawbone and seemed effective for repairing bone defects.