Disengagement of motor cortex from movement control during long-term learning
Disengagement of motor cortex from movement control during long-term learning
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DOI：
10.1126/sciadv.aay0001
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发表时间：
2019-10-01
期刊：
影响因子：
13.6
通讯作者：
Komiyama, Takaki
中科院分区：
文献类型：
--
作者：
Hwang, Eun Jung;Dahlen, Jeffrey E.;Komiyama, Takaki
运动学习涉及初级运动皮层 (M1) 的重组。然而，目前尚不清楚 M1 在运动控制中的参与在长期学习过程中如何变化。为了解决这个问题，我们对小鼠进行了数月的基于前肢的运动任务训练，并在长期训练期间对 M1 进行了光遗传学失活和双光子钙成像。我们发现M1失活在早期和中期损害了前肢运动，但在晚期则没有损害，这表明最初需要M1的运动变得独立于M1。如前所述，从早期到中期的试验中，M1 群体活动变得更加一致，同时任务表现迅速提高。然而，从中期到后期，尽管专家行为一致，但 M1 种群活动再次变得不稳定。后来活动一致性的下降表明 M1 与运动之间的分离。这些发现表明，长期运动学习可以使 M1 脱离运动控制。
Motor learning involves reorganization of the primary motor cortex (M1). However, it remains unclear how the involvement of M1 in movement control changes during long-term learning. To address this, we trained mice in a forelimb-based motor task over months and performed optogenetic inactivation and two-photon calcium imaging in M1 during the long-term training. We found that M1 inactivation impaired the forelimb movements in the early and middle stages, but not in the late stage, indicating that the movements that initially required M1 became independent of M1. As previously shown, M1 population activity became more consistent across trials from the early to middle stage while task performance rapidly improved. However, from the middle to late stage, M1 population activity became again variable despite consistent expert behaviors. This later decline in activity consistency suggests dissociation between M1 and movements. These findings suggest that long-term motor learning can disengage M1 from movement control.