Synaptic Effects of Antidepressants
Synaptic Effects of Antidepressants
复制标题
抗抑郁药的突触效应
DOI：
10.1097/00004714-199606002-00001
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发表时间：
1996
影响因子：
2.9
通讯作者：
E. Richelson
中科院分区：
文献类型：
--
作者：
E. Richelson
儿茶酚胺，特别是去甲肾上腺素（NE）和5-羟色胺（5-HT），已被牵连在抑郁症的病理生理。然而，它们的确切作用及其相互关系并不完全清楚。抗抑郁药对身体有各种影响，包括对大脑神经元突触的作用;这些影响中最重要的两个是阻断神经递质的再摄取，包括NE，5-HT和多巴胺，以及阻断某些神经递质受体。目前可用的抗抑郁药可分类为单胺氧化酶抑制剂或生物胺神经递质再摄取阻断剂，后者最好地描述了三环抗抑郁药和选择性5-HT-再摄取抑制剂，因为它们阻断一种或多种神经递质的再摄取。然而，最近推出的抗抑郁药，如5-HT-NE再摄取抑制剂，具有与旧化合物不同的突触作用。这些突触效应在解释与所有类别的抗抑郁药相关的某些副作用和药物相互作用方面很重要。本文综述了上市的抗抑郁药的突触作用，以阐明这些药物的预期副作用和药物相互作用的潜力。
Catecholamines, especially norepinephrine (NE) and serotonin (5-hydroxytryptamine [5-HT]), have been implicated in the pathophysiology of depression. However, their exact roles and their interrelationship are not completely understood. Antidepressants have various effects on the body, including action at the neuronal synapses of the brain; the two most important of these effects are blockade of the reuptake of neurotransmitters, including NE, 5-HT, and dopamine, and blockade of certain neurotransmitter receptors. Currently available antidepressants may be classified as inhibitors of monoamine oxidase or as blockers of biogenic amine neurotransmitter reuptake, the latter best describing tricyclic antidepressants and selective 5-HT-reuptake inhibitors, because they block the reuptake of one or more neurotransmitters. However, recently introduced antidepressants, such as the 5-HT-NE-reuptake inhibitors, have synaptic effects that differ from those of older compounds. These synaptic effects are important in explaining certain side effects and drug-drug interactions associated with all classes of antidepressants. This article reviews the synaptic effects of marketed antidepressant agents to elucidate the anticipated side effects and drug-interaction potential of these agents.
DOI：
--
发表时间：
1984-07
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
E. Richelson;A. Nelson
通讯作者：
E. Richelson;A. Nelson
影响因子：
6.1
作者：
BOLDENWATSON, C;RICHELSON, E
通讯作者：
RICHELSON, E
抗抑郁药的药理学——理想药物的特征。
影响因子：
8.9
作者：
Richelson,E
通讯作者：
Richelson,E