Early Changes of Some Serum Proteins and Metals in Diabetic Children
Early Changes of Some Serum Proteins and Metals in Diabetic Children
复制标题
DOI：
10.1111/j.1651-2227.1988.tb10739.x
复制
发表时间：
1988-09
期刊：
影响因子：
--
通讯作者：
A. M. Kobbah;K. Hellsing;T. Tuvemo
中科院分区：
文献类型：
--
作者：
A. M. Kobbah;K. Hellsing;T. Tuvemo
抽象的。本文对30例3~15岁新诊断的IDDM患儿和44例健康儿童进行了血清前白蛋白、白蛋白、类粘蛋白、镁、锌和钙的测定。IDDM患儿入院时血清前白蛋白(149±48 mg/l)(M±SD)显著低于健康对照组(194±39 mg/l)(p<；.001)。两年随访前白蛋白明显升高，但未达到健康对照水平。血清白蛋白在确诊时略有升高(p<；0.01)，但后来显著下降(p<；0.01)。糖尿病患者和对照组之间的OroSomucid浓度没有差异。血清镁最初在参考区间内，但后来下降，在糖尿病2年后非常显著地下降(p<；0.001)。胰岛素依赖型糖尿病儿童在确诊时血清锌显著降低(p<；0.001)，但在一年和两年后仍在参考区间内。IDDM组在确诊时血钙升高(p<；0.01)，但后来恢复正常。结论：早期IDDM患者血清前白蛋白和白蛋白下降，血清镁呈进行性下降，血清锌呈一过性下降。
ABSTRACT. Serum concentrations of prealbumin, albumin, orosomucoid, magnesium, zinc and calcium were studied in 30 children with newly diagnosed IDDM aged 3–15 years, during the first two years of the disease, and in 44 healthy control children. On admission serum prealbumin was significantly lower in IDDM children (149±48 mg/1) (M±SD) than in healthy controls (194±39 mg/1) (p<.001). During the two years follow‐up prealbumin increased significantly, but did not reach the level of healthy controls. Serum albumin was slightly increased at diagnosis (p<0.01), but later decreased significantly (p<0.01). Orosomucoid concentrations did not differ between diabetics and controls. Serum magnesium was initially within the reference interval but later decreased, and after 2 years of IDDM it was highly significantly reduced (p<0.001). Serum zinc was significantly reduced in IDDM children at diagnosis (p<0.001), but was within the reference interval after one and 2 years. Serum calcium was increased in the IDDM group at diagnosis (p<0.01), but later normalized. It is concluded that in early IDDM there is a decrease in serum prealbumin and albumin, and serum magnesium decreases progressively, while serum zinc is only transiently reduced.