Impact of MUC1 Expression on the Progression of Intraductal Papillary Mucinous Neoplasm With Worrisome Features During Follow-up.
Impact of MUC1 Expression on the Progression of Intraductal Papillary Mucinous Neoplasm With Worrisome Features During Follow-up.
复制标题
MUC1 表达对随访期间具有令人担忧特征的导管内乳头状粘液性肿瘤进展的影响。
DOI：
10.1097/mpa.0000000000000902
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Watanabe S.
中科院分区：
文献类型：
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作者：
Tomishima K;Sai JK;Kanazawa R;Miura H;Shimizu R;Sato K;Ishii S;Saito H;Ito T;Fukumura Y;Shiina S;Watanabe S.
目的本研究的目的是调查MUC1表达是否与导管内乳头状黏液性肿瘤的进展有关，在随访过程中有令人担忧的特征。MUC1组和16例MUC1和MUC2阴性患者（对照组）随访并检查胰管主支和扩张支的直径变化、壁结节增大和实性肿块的外观，通过成像研究。所有这些人都表现出令人担忧的特征，没有一个人有“高风险的烙印”。结果MUC 1组胰管主干和扩张支增大者分别为8例（53.3%）和8例（53.3%），对照组分别为1例（6.3%）和1例（6.3%）（P= 0.0059和0.0059）。MUC1组6例（33.3%）出现实性肿块，而对照组无一例（P= 0.0373）。结论MUC1阳性表达可能与胰腺导管主支和扩张支的进行性扩张有关，并与导管内乳头状黏液性肿瘤患者在随访过程中出现实性肿块有关。
ObjectivesThe aim of this study was to investigate whether MUC1 expression is associated with progression of intraductal papillary mucinous neoplasms with worrisome features during follow-up.MethodsFifteen patients positive for MUC1 and negative for MUC2 (MUC1 group) and 16 patients negative for MUC1 and MUC2 (control group) were followed up and examined for changes in diameters of the main and ectatic branches of pancreatic ducts, enlargement of mural nodules, and appearance of a solid mass, by imaging studies. All of them presented worrisome features, and none had “high-risk stigmata.”ResultsThe sizes of the main and ectatic branches of pancreatic ducts increased in 8 (53.3%) and 8 (53.3%) patients, respectively, of the MUC1 group and in 1 (6.3%) and 1 (6.3%) patients, respectively, of the control group (P= 0.0059 and 0.0059, respectively). A solid mass developed in 6 patients (33.3%) of the MUC1 group but in none of the control group patients (P= 0.0373).ConclusionsPositive MUC1 expression in cell block cytology specimens may be associated with progressive dilation of the main and ectatic branches of pancreatic ducts and appearance of a solid mass in patients with intraductal papillary mucinous neoplasm with worrisome features during follow-up.