Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men
Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men
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DOI：
10.1007/s10552-007-9066-9
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发表时间：
2008-02-01
影响因子：
2.3
通讯作者：
Kristal, Alan R.
中科院分区：
文献类型：
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作者：
Gong, Zhihong;Agalliu, Ilir;Kristal, Alan R.
目的本研究的目的是研究在诊断时吸烟与前列腺癌死亡风险的关系，在一个以人群为基础的前列腺癌队列中，数据来自752例年龄在40-64岁的前列腺癌患者，他们被纳入一项病例对照研究，并进行长期随访的死亡率。考克斯比例风险模型被用来估计风险比（HR）和95%置信区间（CI）吸烟和前列腺癌特异性和其他原因mortarity.Results相比，从不吸烟，吸烟在诊断时与前列腺癌特异性死亡率的风险显着增加。在控制了人口统计学特征、Gleason分级、诊断时的分期和初次治疗后，HR为2.66（95%CI：1.10-6.43）。结论诊断时吸烟与前列腺癌死亡风险增加相关，与关键临床预后因素无关。
Objective The aim of this study was to examine associations of smoking at the time of diagnosis with the risk of prostate cancer death in a population-based cohort of men with prostate cancer.Methods Data were from 752 prostate cancer patients aged 40-64 years, who were enrolled in a case-control study and under long-term follow-up for mortality. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between smoking and prostate cancer-specific and other cause mortality.Results Compared to never smoking, smoking at the time of diagnosis was associated with a significant increase in risk of prostate cancer-specific mortality. After controlling for demographic characteristics, Gleason grade, stage at diagnosis, and primary treatment, the HR was 2.66 (95% CI: 1.10-6.43).Conclusions Smoking at the time of diagnosis, independent of key clinical prognostic factors, is associated with an increased risk of prostate cancer death.